Synthesis of pyrimidine derivatives based on ethyl 2-ethoxymethylidene-3-polyfluoroalkyl-3-oxopropionates and urea / Goryaeva M. V.,Burgart Ya. V.,Saloutin V. I. // RUSSIAN CHEMICAL BULLETIN. - 2009. - V. 58, l. 6. - P. 1259-1263.

ISSN/EISSN:

1066-5285 / 1573-9171

Type:

Article

Abstract:

Ethyl 2-ethoxymethylidene-3-polyfluoroalkyl-3-oxopropionates under mild conditions undergo regioselective condensation with urea at the ethoxymethylidene substituent giving rise to ethyl 3-polyfluoroalkyl-3-oxo-2-(ureidomethylidene)propionates. Under more drastic conditions, the latter cyclize at the fluoroacyl fragment to form ethyl 4-polyfluoroalkyl-4-hydroxy-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxy lates.

Author keywords:

ethyl 2-ethoxymethylidene-3-polyfluoroalkyl-3-oxopropionates; urea; pyrimidines; cyclization; isomerism INHIBITORS

DOI:

10.1007/s11172-009-0164-6

Web of Science ID:

ISI:000277098500023

Соавторы в МНС:

Другие поля

Поле	Значение
Month	JUN
Publisher	SPRINGER
Address	233 SPRING ST, NEW YORK, NY 10013 USA
Language	English
EISSN	1573-9171
Keywords-Plus	INHIBITORS
Research-Areas	Chemistry
Web-of-Science-Categories	Chemistry, Multidisciplinary
Author-Email	saloutin@ios.uran.ru
ResearcherID-Numbers	Burgart, Yanina/T-8025-2017
ORCID-Numbers	Burgart, Yanina/0000-0001-6061-2410
Funding-Acknowledgement	Russian Foundation for Basic Research {[}09-03-00274a]; Council on Grants of the President of the Russian Federation {[}NSh 3758.2008.3]
Funding-Text	This work was financially supported by the Russian Foundation for Basic Research (Project No. 09-03-00274a) and the Council on Grants of the President of the Russian Federation (Program for the State Support of Leading Scientific Schools, Grant NSh 3758.2008.3).
Number-of-Cited-References	23
Usage-Count-Since-2013	3
Journal-ISO	Russ. Chem. Bull.
Doc-Delivery-Number	588UB