Fluorocontaining 1,3-dicarbonyl compounds in the synthesis of pyrimidine derivatives / Burgart YV,Kuzueva OG,Pryadeina MV,Kappe CO,Saloutin VI // RUSSIAN JOURNAL OF ORGANIC CHEMISTRY. - 2001. - V. 37, l. 6. - P. 869-880.

ISSN/EISSN:

1070-4280 / нет данных

Type:

Article

Abstract:

Hexafluoroacetylacetone reacts with urea (thiourea) to yield respectively 4,6-bis(hydroxy)-4,6-bis(trifluoromethyl)hexahydropyrimidin-2-one(thione ). The dehydration of the products and also reaction of nonsymmetrical fluoroalkyl-containing 1,3-diketones with urea (thiourea) afford substituted pyrimidines. The condensation of fluorinated 3-oxoesters and 1,3-diketones with benzaldehyde and urea (thiourea) results in 5-alkoxycarbonyl(acyl)-4-hydroxy-2-oxo(thioxo)-6-phenyl-4-fluoroalkylhex ahydropyrimidines that on dehydration furnish 5-alkoxycarbonyl(acyl)-2-oxo(thioxo)-4-phenyl-6-fluoroalkyltetrahydropyr imidines. Ethyl 7-nonafluorobutyl-5-phenyl-2,3-dihydrothiazolo{[}3,2-a]pyrimidine-6-carb oxylate hydrobromide forms in reaction of dibromoethane with ethyl ether of 2-thioxo-4-phenyl-6-nonafluorobutyltetrahydropyrimidine.

Author keywords:

CONTAINING BETA-DIKETONES

DOI:

10.1023/A:1012473901354

Web of Science ID:

ISI:000171938500017

Соавторы в МНС:

Другие поля

Поле	Значение
Month	JUN
Publisher	MAIK NAUKA/INTERPERIODICA
Address	C/O KLUWER ACADEMIC-PLENUM PUBLISHERS, 233 SPRING ST, NEW YORK, NY 10013-1578 USA
Language	English
Keywords-Plus	CONTAINING BETA-DIKETONES
Research-Areas	Chemistry
Web-of-Science-Categories	Chemistry, Organic
ResearcherID-Numbers	Burgart, Yanina/T-8025-2017 Kappe, C. Oliver/C-9771-2011
ORCID-Numbers	Burgart, Yanina/0000-0001-6061-2410 Kappe, C. Oliver/0000-0003-2983-6007
Number-of-Cited-References	19
Usage-Count-Since-2013	1
Journal-ISO	Russ. J. Organ. Chem.
Doc-Delivery-Number	488MG