Synthesis of 2-(1-alkyl(aryl)-4-oxo-5,6,7,8-tetrafluoro-1, 4-dihydroquinolin-3-yl)glyoxylic acid derivatives / Fokin AS,Burgart YV,Saloutin VI,Chupakhin ON // JOURNAL OF FLUORINE CHEMISTRY. - 2001. - V. 108, l. 2. - P. 187-194.

ISSN/EISSN:

0022-1139 / нет данных

Type:

Article

Abstract:

Methods for synthesis of previously unknown 2-(1-alkyl(aryl)-4-oxo-5,6,7,8-tetrafluoro-1,4-dihydroquinolin-3-yl)glyo xylic acids and their esters from the copper chelate of ethyl pentafluorobenzoylpyruvate were developed. 1-Aryl(alkyl)-3-ethoxalyl-5,6,7,8-tetrafluoro-quinolin-4-ones react with o-phenylenediamine and o,-aminophenol to give the corresponding quinolin-3-ylquinoxalones and quinolin-3-ylbenzoxazines. The same heterocycles act with o-aminothiophenol to yield ethyl-2-(7-(2-aminophenylthio)-1-aryl-5,6,8-trifluoro-quinolon-3-yl)-2-( 2-mercaptophenylimino)glioxylates. Interaction of 1-aryl-3-ethoxalyl-(heteryl)-5,6,7,8-tetrafluoroquinolones with morpholine gives 7-mono- and 5,7-disubstituted products depending on the reaction conditions. (C) 2001 Elsevier Science B.V. All rights reserved.

Author keywords:

ethyl pentafluorobenzoylpyruvate; 3-ethoxalyl-5,6,7-8-tetrafluoroquinolin-4-ones; 2-(1-alkyl(aryl)-5,6,7,8-tetrafluoro-4-oxo-1,4-dihydroquinolin-3-yl)glyo xylic acids; o-phenylenediamine; o-aminopheno

DOI:

10.1016/S0022-1139(01)00354-2

Web of Science ID:

ISI:000168879700007

Соавторы в МНС:

Другие поля

Поле	Значение
Month	MAY
Publisher	ELSEVIER SCIENCE SA
Address	PO BOX 564, 1001 LAUSANNE, SWITZERLAND
Language	English
Research-Areas	Chemistry
Web-of-Science-Categories	Chemistry, Inorganic \& Nuclear; Chemistry, Organic
ResearcherID-Numbers	Burgart, Yanina/T-8025-2017
ORCID-Numbers	Burgart, Yanina/0000-0001-6061-2410
Number-of-Cited-References	6
Journal-ISO	J. Fluor. Chem.
Doc-Delivery-Number	435KB