Novel synthetic routes to N-(2-amino-9H-purin-6-yl)-substituted amino acids / Vigorov Alexey Yu.,Krasnov Viktor P.,Gruzdev Dmitry A.,Men'shikova Alisa A.,Demin Alexander M.,Levit Galina L.,Charushin Valery N. // MENDELEEV COMMUNICATIONS. - 2014. - V. 24, l. 1. - P. 35-36.

ISSN/EISSN:
0959-9436 / 1364-551X
Type:
Article
Abstract:
Reaction of N-2-protected 2-amino-6-chloropurine with tert-butyl (S)-phenylalaninate, (R)- and (S)-valinates followed by deprotection affords 2-aminopurines bearing at 6-position the corresponding amino acid moieties, whose chiral centre is partially racemized.
Author keywords:
ACYCLIC NUCLEOSIDE PHOSPHONATES; DELIVERY-SYSTEMS; DERIVATIVES; PRODRUGS; VIRUS; DRUGS
DOI:
10.1016/j.mencom.2013.12.011
Web of Science ID:
ISI:000331163400011
Соавторы в МНС:
Другие поля
Поле Значение
Month JAN-FEB
Publisher ELSEVIER SCIENCE BV
Address PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
Language English
EISSN 1364-551X
Keywords-Plus ACYCLIC NUCLEOSIDE PHOSPHONATES; DELIVERY-SYSTEMS; DERIVATIVES; PRODRUGS; VIRUS; DRUGS
Research-Areas Chemistry
Web-of-Science-Categories Chemistry, Multidisciplinary
Author-Email ca@ios.uran.ru
ResearcherID-Numbers Demin, Alexander/L-7353-2016
ORCID-Numbers Demin, Alexander/0000-0002-4132-2327
Funding-Acknowledgement Russian Foundation for Basic Research {[}12-03-33029]; Ural Branch of the Russian Academy of Sciences {[}12-P-3-1030]; State Program for Supporting of Leading Scientific Schools of the Russian Federation {[}NSh-5505.2012.3]
Funding-Text The authors are grateful to Dr. A. A. Tumashov and M. S. Toporova for performing HPLC analyses, Dr. I. N. Ganebnykh for registration of LC-MS spectra, and Dr. M. I. Kodess for registration of NMR spectra. This work was supported by the Russian Foundation for Basic Research (grant no. 12-03-33029), the Ural Branch of the Russian Academy of Sciences (grant no. 12-P-3-1030) and the State Program for Supporting of Leading Scientific Schools of the Russian Federation (grant no. NSh-5505.2012.3).
Number-of-Cited-References 22
Usage-Count-Last-180-days 2
Usage-Count-Since-2013 14
Journal-ISO Mendeleev Commun.
Doc-Delivery-Number AA5TV