Structures of the racemate and (S)-enantiomer of 7,8-difluoro-3-methyl-2,3-dihydro-4H-{[}1,4]benzoxazine / Slepukhin P. A.,Gruzdev D. A.,Chulakov E. N.,Levit G. L.,Krasnov V. P.,Charushin V. N. // RUSSIAN CHEMICAL BULLETIN. - 2011. - V. 60, l. 5. - P. 955-960.

ISSN/EISSN:

1066-5285 / нет данных

Type:

Article

Abstract:

The comparative X-ray diffraction study of racemic and (S)-enantiomer of 7,8-difluoro-3-methyl-2,3-dihydro-4H-{[}1,4]benzoxazine was carried out. The both forms of benzoxazine are crystallized in the orthorhombic crystal system, the (S)-enantiomer is crystallized in the chiral space group P2(1)2(1)2(1), while the racemate is crystallized in the centrosymmetric Pbca space group. The bond lengths and bond and torsional angles in the both molecules are almost equal. The packing of the racemate is characterized by a closer interaction of polar NHaEuro broken vertical bar O groups.

Author keywords:

X-ray diffraction analysis; enantiomers; racemates; 2,3-dihydro-4H-{[}1,4]benzoxazines; organofluorine compounds OPTICALLY-ACTIVE OFLOXACIN; ANTIBACTERIAL ACTIVITIES; KEY INTERMEDIATE; LEVOFLOXACIN; RESOLUTION; CYCLIZATION; REDUCTION

DOI:

нет данных

Web of Science ID:

ISI:000297153800026

Соавторы в МНС:

Другие поля

Поле	Значение
Month	MAY
Publisher	SPRINGER
Address	233 SPRING ST, NEW YORK, NY 10013 USA
Language	English
Keywords-Plus	OPTICALLY-ACTIVE OFLOXACIN; ANTIBACTERIAL ACTIVITIES; KEY INTERMEDIATE; LEVOFLOXACIN; RESOLUTION; CYCLIZATION; REDUCTION
Research-Areas	Chemistry
Web-of-Science-Categories	Chemistry, Multidisciplinary
Author-Email	slepukhin@ios.uran.ru
Funding-Acknowledgement	Russian Foundation for Basic Research {[}10-03-00084]; Russian Federation {[}NSh-65261.2010.3]; Ministry of Education and Science of the Russian Federation {[}02.522.12.2011]; Ural Branch of the Russian Academy of Sciences {[}09-P-3-2001, 09-I-3-2004]
Funding-Text	This work was financially supported by the Russian Foundation for Basic Research (Project No. 10-03-00084), the Council on Grants at the President of the Russian Federation (Program for State Support of Leading Scientific Schools, Grant NSh-65261.2010.3), the Ministry of Education and Science of the Russian Federation (State Contract No. 02.522.12.2011), and the Ural Branch of the Russian Academy of Sciences (Project Nos 09-P-3-2001 and 09-I-3-2004).
Number-of-Cited-References	17
Usage-Count-Since-2013	2
Journal-ISO	Russ. Chem. Bull.
Doc-Delivery-Number	849VQ