Kinetic resolution of heterocyclic amines by reaction with optically active acid chlorides. The effect of reaction conditions on the diastereoselectivity of acylation of (+/-)-3-methyl-2,3-dihydro-4H-1,4-benzoxazine / Krasnov VP,Levit GL,Korolyova MA,Bukrina IM,Sadretdinova LS,Andreeva IN,Charushin VN,Chupakhin ON // RUSSIAN CHEMICAL BULLETIN. - 2004. - V. 53, l. 6. - P. 1253-1256.

ISSN/EISSN:

1066-5285 / нет данных

Type:

Article

Abstract:

The influence of the reaction conditions (solvent, base) on the diastereoselectivity of acylation of (+/-)-3-methyl-2,3-dihydro-4H-1,4-benzoxazine with (S)-naproxen and N-tosyl(S)-proline chlorides was studied. The highest diastereoselectivity was observed for the reaction carried out in benzene in the presence of aliphatic tertiary amines.

Author keywords:

kinetic resolution of racemates; 3-methyl-2,3-dihydro-4H-1,4-benzoxazine; acid chlorides; (S)-naproxen; N-tosyl-(S)-proline; acylation ALCOHOLS; CATALYSTS

DOI:

10.1023/B:RUCB.0000042282.2976

Web of Science ID:

ISI:000224147800017

Соавторы в МНС:

Другие поля

Поле	Значение
Month	JUN
Publisher	CONSULTANTS BUREAU
Address	233 SPRING ST, NEW YORK, NY 10013 USA
Language	English
Keywords-Plus	ALCOHOLS; CATALYSTS
Research-Areas	Chemistry
Web-of-Science-Categories	Chemistry, Multidisciplinary
Author-Email	ca@ios.uran.ru
Number-of-Cited-References	17
Usage-Count-Since-2013	1
Journal-ISO	Russ. Chem. Bull.
Doc-Delivery-Number	857VR