Efficient large (ca.40 g) laboratory scale preparation of (S)- and (R)-valine tert-butyl esters / Krasnov VP,Levit GL,Bukrina IM,Demin AM,Chupakhin ON,Yoo JU // TETRAHEDRON-ASYMMETRY. - 2002. - V. 13, l. 17. - P. 1911-1914.

ISSN/EISSN:

0957-4166 / нет данных

Type:

Article

Abstract:

A large laboratory scale (ca. 40 g) method for the preparation of enantiomerically pure (S)- and (R)-valine tert-butyl esters has been developed. The method involves three steps: preparation of N-TFA-valines, preparation of valine tert-butyl esters using 2-methylpropene in dioxane in the presence of sulfuric acid, and isolation of the tat-get compounds Lis the acetate derivative. The overall yield is up to 70\% relative to the starting valine, ee being more than 98\% (by HPLC). (C) 2002 Elsevier Science Ltd. All rights reserved.

Author keywords:

DERIVATIVES; ACIDS

DOI:

10.1016/S0957-4166(02)00532-3

Web of Science ID:

ISI:000178467400012

Соавторы в МНС:

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Другие поля

Поле	Значение
Month	SEP 9
Publisher	PERGAMON-ELSEVIER SCIENCE LTD
Address	THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
Language	English
Article-Number	PII S0957-4166(02)00532-3
Keywords-Plus	DERIVATIVES; ACIDS
Research-Areas	Chemistry
Web-of-Science-Categories	Chemistry, Inorganic \& Nuclear; Chemistry, Organic; Chemistry, Physical
ResearcherID-Numbers	Demin, Alexander/L-7353-2016
Number-of-Cited-References	19
Usage-Count-Since-2013	3
Journal-ISO	Tetrahedron: Asymmetry
Doc-Delivery-Number	601UU