Identification and analytical characteristics of synthetic cannabinoids with an indazole-3-carboxamide structure bearing a N-1-methoxycarbonylalkyl group / Shevyrin Vadim,Melkozerov Vladimir,Nevero Alexander,Eltsov Oleg,Shafran Yuri,Morzherin Yuri,Lebedev Albert T. // ANALYTICAL AND BIOANALYTICAL CHEMISTRY. - 2015. - V. 407, l. 21. - P. 6301-6315.

ISSN/EISSN:

1618-2642 / 1618-2650

Type:

Article

Abstract:

Illicit new psychoactive substances (NPS) are a serious threat to health throughout the world. Such NPS do not usually pass preliminary pharmacological trials. In 2014, we identified a series of five new synthetic cannabinoids with an indazole-3-carboxamide structure bearing an N-1-methoxycarbonylalkyl group. The compounds have very high cannabimimetic activity which has caused mass severe intoxication and deaths. The compounds were identified by means of gas chromatography-mass spectrometry (GC-MS), including high-resolution mass spectrometry (GC-HRMS), ultra-high-performance liquid chromatography-high-resolution tandem mass spectrometry (UHPLC-HRMS2), and H-1 and C-13 nuclear magnetic resonance spectroscopy (NMR). The peculiarities of mass-spectral fragmentation of the compounds after electron ionization (EI) ionization and collision-induced dissociation (CID) were studied. The analytical characteristics reported for the compounds will enable their identification in a variety of materials seized from criminals. Graphical Abstract.

Author keywords:

Synthetic cannabinoids; New psychoactive substances; Indazole-3-carboxamides; High-resolution mass spectrometry; Chromatography; NMR MASS-SPECTROMETRY; ILLEGAL PRODUCTS; DESIGNER DRUGS; DERIVATIVES; REPRESENTATIVES; IMMUNOASSAY; METABOLITES; FUBINACA; URINE

DOI:

10.1007/s00216-015-8612-7

Web of Science ID:

ISI:000358646400007

Соавторы в МНС:

Другие поля

Поле	Значение
Month	AUG
Publisher	SPRINGER HEIDELBERG
Address	TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
Language	English
EISSN	1618-2650
Keywords-Plus	MASS-SPECTROMETRY; ILLEGAL PRODUCTS; DESIGNER DRUGS; DERIVATIVES; REPRESENTATIVES; IMMUNOASSAY; METABOLITES; FUBINACA; URINE
Research-Areas	Biochemistry \& Molecular Biology; Chemistry
Web-of-Science-Categories	Biochemical Research Methods; Chemistry, Analytical
Author-Email	a.lebedev@org.chem.msu.ru
ResearcherID-Numbers	Morzherin, Yury/M-7420-2013 Shevyrin, Vadim/F-2416-2017
ORCID-Numbers	Morzherin, Yury/0000-0002-1333-6676 Shevyrin, Vadim/0000-0002-0369-0786
Number-of-Cited-References	33
Usage-Count-Last-180-days	1
Usage-Count-Since-2013	26
Journal-ISO	Anal. Bioanal. Chem.
Doc-Delivery-Number	CN7WV