Synthesis of spiro derivatives of 1,2,3-triazolo[5,1-b][1,3,4]thiadiazines and biological activity thereof / Kalinina T.A., Bystrykh O.A., Pozdina V.A., Glukhareva T.V., Ulitko M.V., Morzherin Y.Y. // Chemistry of Heterocyclic Compounds. - 2015. - V. 51, l. 6. - P. 589-592.

ISSN:

00093122

Type:

Article

Abstract:

[MediaObject not available: see fulltext.] 3-Cyclopentylidene(cyclohexylidene)amino-3H-1,2,3-triazole-4-thiolates, formed via Dimroth rearrangement of 1,2,3-thiadiazolylhydrazones of cyclopentanone and cyclohexanone in the presence of triethylamine, reacted in situ with α-bromoacetophenones with the formation of spirocyclic 6,7-dihydro-5H-[1,2,3]triazolo[5,1-b][1,3,4]thiadiazines. The effect of the obtained compounds on the viability and proliferative activity of four lines of cell cultures was studied. The selective proliferative activity was determined. © 2015 Springer Science+Business Media New York.

Author keywords:

1,2,3-triazoles; 1,3,4-thiadiazines; continuous cell lines; cytotoxicity; dermal fibroblasts; Dimroth rearrangement; MTT assay; proliferation; spirocyclic compounds

Index keywords:

нет данных

DOI:

10.1007/s10593-015-1742-1

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https://www.scopus.com/inward/record.uri?eid=2-s2.0-84938977897&doi=10.1007%2fs10593-015-1742-1&partnerID=40&md5=1faa16f8806293dd0dc51130349edf39

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Link	https://www.scopus.com/inward/record.uri?eid=2-s2.0-84938977897&doi=10.1007%2fs10593-015-1742-1&partnerID=40&md5=1faa16f8806293dd0dc51130349edf39
Affiliations	Ural Federal University Named after the First Russian Prezident B. N. Yeltzin, 19 Mir St., Yekaterinburg, Russian Federation; Institute of Medical Cell Technologies, 22a Karl Marks St., Yekaterinburg, Russian Federation
Author Keywords	1,2,3-triazoles; 1,3,4-thiadiazines; continuous cell lines; cytotoxicity; dermal fibroblasts; Dimroth rearrangement; MTT assay; proliferation; spirocyclic compounds
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Correspondence Address	Morzherin, Y.Y.; Ural Federal University Named after the First Russian Prezident B. N. Yeltzin, 19 Mir St., Russian Federation; email: yu.yu.morzherin@urfu.ru
Publisher	Springer New York LLC
CODEN	CHCCA
Language of Original Document	English
Abbreviated Source Title	Chem. Heterocycl. Compd.
Source	Scopus