Synthesis of new 2-substituted 3-(tri(di)fluoromethyl)-quinoxalines from 3-(trifluoromethyl)quinoxalin-2(1H)-one and 3-(tri(di)fluoromethyl)quinoxaline-2-carboxylic acids / Didenko Andrey V.,Vorobiev Mikhail V.,Sevenard Dmitri V.,Sosnovskikh Vyacheslav Ya. // CHEMISTRY OF HETEROCYCLIC COMPOUNDS. - 2015. - V. 51, l. 3. - P. 259-268.

ISSN/EISSN:

0009-3122 / 1573-8353

Type:

Article

Abstract:

{[}GRAPHICS] Starting from 3-(trifluoromethyl)quinoxalin-2(1H)-one, a wide range of new 2-substituted 3-(trifluoromethyl)quinoxalines were obtained, including amino, bromo, chloro, hydrazino, phenyl, alpha-furyl, formyl, methylsulfanyl, and methylsulfonyl derivatives. 3-(Tri(di)-fluoromethyl)quinoxaline-2-carboxylic acids were obtained for the first time and used for the synthesis of 2-amino-3-(tri(di)-fluoromethyl)quinoxalines and 2-(2-aminothiazol-4-yl)-3-(trifluoromethyl)quinoxaline.

Author keywords:

quinoxaline-2-carboxylic acid; quinoxaline-2(1H)-thione; quinoxalin-2(1H)-one; 2-substituted 3-(tri(di)fluoromethyl)-quinoxalines BIOLOGICAL EVALUATION; ANTICANCER ACTIVITY; HETEROCYCLES; TRIFLUOROMETHYLATION; PERFLUOROBIACETYL; RECEPTOR; REAGENT; FACILE

DOI:

10.1007/s10593-015-1694-5

Web of Science ID:

ISI:000354479700009

Соавторы в МНС:

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Другие поля

Поле	Значение
Month	MAR
Publisher	SPRINGER
Address	233 SPRING ST, NEW YORK, NY 10013 USA
Language	English
EISSN	1573-8353
Keywords-Plus	BIOLOGICAL EVALUATION; ANTICANCER ACTIVITY; HETEROCYCLES; TRIFLUOROMETHYLATION; PERFLUOROBIACETYL; RECEPTOR; REAGENT; FACILE
Research-Areas	Chemistry
Web-of-Science-Categories	Chemistry, Organic
Author-Email	sevenard@hfc-chemicals.com vy.sosnovskikh@urfu.ru
Funding-Acknowledgement	Federal Ministry of Industry and Technology of Germany {[}EP101205]
Funding-Text	This work was performed with financial support from the Federal Ministry of Industry and Technology of Germany (project EP101205). A part of this research was presented at the conference ``Organic synthesis: chemistry and technology{''
Number-of-Cited-References	39
Usage-Count-Last-180-days	3
Usage-Count-Since-2013	10
Journal-ISO	Chem. Heterocycl. Compds.
Doc-Delivery-Number	CI1CW