EXPERIMENTAL STUDY OF ANTIAGGREGATION EFFECT OF 2-CYCLOALKYLAMINO-5-PHENYL-1,3,4-5H(C2H5)-THIADIAZINES IN VITRO / Logvinova Yu. S.,Vasilyeva T. M.,Makarov V. A.,Chupakhin O. N.,Sidorova L. P.,Perova N. M.,Rusinov V. L. // GEMATOLOGIYA I TRANSFUZIOLOGIYA. - 2013. - V. 58, l. 2. - P. 37-40.

ISSN/EISSN:

0234-5730 / нет данных

Type:

Article

Abstract:

A group of original 1,3,4-thiadiazines, containing cycloalkylamine residues in position 2 of 1,3,4-thiadiazine ring, were tested for antiaggregation activity in vitro. All the studied compounds reduced platelet aggregation induced by ADP and arachidonic acid. The most active inhibitors of ADP-induced platelet aggregation were L-52, L-59 compounds with hexamethylenimine residues and L-58 compound with morfoline residue in position 2 of 1,3,4-thiadiazine ring. Compound L-36 - 1,3,4-thiadiazine with thiomorfoline residue - proved to be the most active antiaggregant in platelet aggregation induced by arachidonic acid.

Author keywords:

platelet aggregation; 1,3,4-thiadiazines BLOOD

DOI:

нет данных

Web of Science ID:

ISI:000323692300007

Соавторы в МНС:

Другие поля

Поле	Значение
Month	APR-JUN
Publisher	MINISTERSTVO ZDRAVOOKHRANENIYA
Address	NAUCHNIY PROEZD 6, B-246 MOSCOW, RUSSIA
Language	Russian
Keywords-Plus	BLOOD
Research-Areas	Hematology
Web-of-Science-Categories	Hematology
Author-Email	logvinova\_yuliya@list.ru
ORCID-Numbers	Makarov, Vladimir/0000-0002-2922-3246
Number-of-Cited-References	15
Usage-Count-Last-180-days	1
Usage-Count-Since-2013	1
Journal-ISO	Gematol. Transfuziol.
Doc-Delivery-Number	208PT