Synthesis of spiro derivatives of 1,2,3-triazolo{[}5,1-b]{[}1,3,4]thiadiazines and biological activity thereof / Kalinina Tatiana A.,Bystrykh Olga A.,Pozdina Varvara A.,Glukhareva Tatiana V.,Ulitko Maria V.,Morzherin Yuri Yu. // CHEMISTRY OF HETEROCYCLIC COMPOUNDS. - 2015. - V. 51, l. 6. - P. 589-592.

ISSN/EISSN:

0009-3122 / 1573-8353

Type:

Article

Abstract:

3-Cyclopentylidene(cyclohexylidene)amino-3H-1,2,3-triazole-4-thiolates, formed via Dimroth rearrangement of 1,2,3-thiadiazolylhydrazones of cyclopentanone and cyclohexanone in the presence of triethylamine, reacted in situ with alpha-bromoacetophenones with the formation of spirocyclic 6,7-dihydro-5H-{[}1,2,3]triazolo{[}5,1-b]{[}1,3,4]thiadiazines. The effect of the obtained compounds on the viability and proliferative activity of four lines of cell cultures was studied. The selective proliferative activity was determined.

Author keywords:

spirocyclic compounds; 1,3,4-thiadiazines; 1,2,3-triazoles; continuous cell lines; cytotoxicity; dermal fibroblasts; Dimroth rearrangement; MTT assay; proliferation CRYSTAL-STRUCTURE; TRIAZOLOTHIADIAZINES; TRANSFORMATION; SERIES

DOI:

10.1007/s10593-015-1742-1

Web of Science ID:

ISI:000359431000016

Соавторы в МНС:

Другие поля

Поле	Значение
Month	JUN
Publisher	SPRINGER
Address	233 SPRING ST, NEW YORK, NY 10013 USA
Language	English
EISSN	1573-8353
Keywords-Plus	CRYSTAL-STRUCTURE; TRIAZOLOTHIADIAZINES; TRANSFORMATION; SERIES
Research-Areas	Chemistry
Web-of-Science-Categories	Chemistry, Organic
Author-Email	imct@celltechnologies.ru yu.yu.morzherin@urfu.ru
ResearcherID-Numbers	Morzherin, Yury/M-7420-2013 Glukhareva, Tatiana/A-4610-2016 Ulitko, Maria/R-1760-2016
ORCID-Numbers	Morzherin, Yury/0000-0002-1333-6676 Glukhareva, Tatiana/0000-0002-5231-9879 Ulitko, Maria/0000-0003-3193-2903
Funding-Acknowledgement	Russian Foundation for Basic Research {[}13-03-00137]
Funding-Text	The results were obtained within the framework of performing the State assignment. 4.560.2014-K of the Ministry of Education and Science of Russia and supported by the Russian Foundation for Basic Research (grant 13-03-00137).
Number-of-Cited-References	23
Usage-Count-Last-180-days	1
Usage-Count-Since-2013	11
Journal-ISO	Chem. Heterocycl. Compds.
Doc-Delivery-Number	CO8OZ