Electron-conformational transformations govern the temperature dependence of the cardiac ryanodine receptor gating / Moskvin A. S.,Iaparov B. I.,Ryvkin A. M.,Solovyova O. E.,Markhasin V. S. // JETP LETTERS. - 2015. - V. 102, l. 1. - P. 62-68.

ISSN/EISSN:

0021-3640 / 1090-6487

Type:

Article

Abstract:

Temperature influences many aspects of cardiac excitation-contraction coupling, in particular, hypothermia increases the open probability (P (open)) of cardiac sarcoplasmic reticulum (SR) Ca2+-release channels (ryanodine-sensitive RyR channels) rising the SR Ca2+ load in mammalian myocytes. However, to the best of our knowledge, no theoretical models are available for that effect. Traditional Markov chain models do not provide a reasonable molecular mechanistic insight on the origin of the temperature effects. Here in the paper we address a simple physically clear electron-conformational model to describe the RyR gating and argue that a synergetic effect of external thermal fluctuation forces (Gaussian-Markovian noise) and internal friction via the temperature stimulation/suppression of the open-close RyR tunneling probability can be considered as a main contributor to temperature effects on the RyR gating. Results of the computer modeling allowed us to successfully reproduce all the temperature effects observed for an isolated RyR gating in vitro under reducing the temperature: increase in P (open) and mean open time without any significant effect on mean closed. time.

Author keywords:

RETICULUM CALCIUM-RELEASE; TRP CHANNELS; MODEL; CONTRACTION

DOI:

10.1134/S002136401513010X

Web of Science ID:

ISI:000361487700013

Соавторы в МНС:

Другие поля

Поле	Значение
Month	JUL
Publisher	MAIK NAUKA/INTERPERIODICA/SPRINGER
Address	233 SPRING ST, NEW YORK, NY 10013-1578 USA
Language	English
EISSN	1090-6487
Keywords-Plus	RETICULUM CALCIUM-RELEASE; TRP CHANNELS; MODEL; CONTRACTION
Research-Areas	Physics
Web-of-Science-Categories	Physics, Multidisciplinary
Author-Email	alexander.moskvin@urfu.ru
ResearcherID-Numbers	Solovyova, Olga/T-8232-2017
Funding-Acknowledgement	Ministry of Education and Science of the Russian Federation {[}1437, 2725]; Russian Science Foundation {[}14-35-00005]
Funding-Text	This work was supported by the Ministry of Education and Science of the Russian Federation, project nos. 1437 and 2725 (elaboration of the EC model), and the Russian Science Foundation, project no. 14-35-00005 (application to the temperature effects in RyR functioning).
Number-of-Cited-References	20
Usage-Count-Last-180-days	1
Usage-Count-Since-2013	7
Journal-ISO	Jetp Lett.
Doc-Delivery-Number	CR6WB