PREPARATION OF COMPOSITE LIPOSOMES FOR TARGETED DRUG DELIVERY / Kozhikhova V,Ivantsova Maria N.,Shulepov Iliya D.,Ponomarev Vladislav S.,Mironov Maxim A. // . - 2015. - V. , l. . - P. 518-524.

ISSN/EISSN:

нет данных / нет данных

Type:

Proceedings Paper

Abstract:

Nanotechnology is positively impacting the development of modern pharmaceutical industry. One of extensively studied drug delivery systems in clinical practice are liposomes, which have been used for enhancement of the ability to apply highly toxic drugs and overcoming of barriers to cellular and tissue uptake. The objective of the present work was to obtain the stable chitosan-coated liposomes and their interaction with anti-viral drugs. Liposomes were prepared by stepwise extrusion through 0.2 and 0.1 mu m pore sizes using inorganic membranes Anotop. Several series of experiments using the various liposomal compositions were conducted. The liposomal dispersions obtained were compared in terms of particle size, polydispersity index, zeta potential and stability. The optimal composition of the lipid film was selected and the effect of various additives was investigated. It was shown that the addition of the polyethylene glycol - modified natural monoacylglycerides and biocompatible choline derivatives of limiting fatty acids allows to reduce the diameter of the liposomes obtained by the extrusion to 150-155 nm with a polydispersity index of 0.11 - 0.13. Liposomes from the best lipid composition were prepared in a biggest quantity and coated by modified chitosan. It was concluded that appropriate combination of the liposomes and polysaccharide layer might be used for the increasing of colloidal stability up to 5 months and broad functional capabilities for surface modification. Obtained composite liposomes were loaded with selected anti-viral drugs and used as a model objects for the parenteral administration.

Author keywords:

Liposomes; chitosan; extrusion; stability; anti-viral drugs CHITOSAN-COATED LIPOSOMES

DOI:

нет данных

Web of Science ID:

ISI:000350636300089

Соавторы в МНС:

Другие поля

Поле	Значение
Book-Group-Author	TANGER
Booktitle	NANOCON 2014, 6TH INTERNATIONAL CONFERENCE
Note	6th NANOCON International Conference, Brno, CZECH REPUBLIC, NOV 05-07, 2014
Organization	TANGER Ltd; Czech Soc New Mat \& Technologies; Reg Ctr Adv Technologies \& Mat; Mat Res Soc Serbia; Norsk Materialteknisk Selskap
Publisher	TANGER LTD
Address	KELTICKOVA 62, SLEZSKA, OSTRAVA 710 00, CZECH REPUBLIC
Language	English
ISBN	978-80-87294-53-6
Keywords-Plus	CHITOSAN-COATED LIPOSOMES
Research-Areas	Science \& Technology - Other Topics; Physics
Web-of-Science-Categories	Nanoscience \& Nanotechnology; Physics, Applied
Author-Email	m.a.mironov@urfu.ru
ResearcherID-Numbers	Kozhikhova, Ksenia/I-8859-2017 Ivantsova, Maria/R-5878-2016
ORCID-Numbers	Kozhikhova, Ksenia/0000-0001-5124-6826 Ivantsova, Maria/0000-0002-2389-0523
Number-of-Cited-References	10
Usage-Count-Last-180-days	3
Usage-Count-Since-2013	13
Doc-Delivery-Number	BC1ZZ