Design of Multi-Component Reactions: From libraries of compounds to libraries of reactions / Mironov Maxim A. // QSAR \& COMBINATORIAL SCIENCE. - 2006. - V. 25, l. 5-6. - P. 423-431.

ISSN/EISSN:

1611-020X / 1611-0218

Type:

Review

Abstract:

Multi-Component Reactions (MCRs) constitute a methodology to shorter syntheses of natural products or complex molecules similar to natural. Due to the large number of accessible compounds and other advantages, this type of chemistry has become very popular in the community of combinatorial chemists. In the last 5 years combinatorial chemistry is has evolved from the synthesis of libraries based on one scaffold to the synthesis of structurally diverse compounds, better known as diversity-oriented synthesis. Following this trend, the design of MCRs is becoming a tool kit for chemists to explore chemistry space broadly with complex and diverse structures. Various approaches to the creation of novel MCRs including ``union of MCRs{''

Author keywords:

combinatorial chemistry; diversity-oriented synthesis; isocyanides; Multi-Component Reactions; reaction design DYNAMIC COMBINATORIAL CHEMISTRY; ORIENTED ORGANIC-SYNTHESIS; COMPONENT CONDENSATION REACTION; 3-COMPONENT REACTION; DIMETHYL ACETYLENEDICARBOXYLATE; CYCLOADDITION REACTIONS; HETEROCYCLIC-COMPOUNDS; 7-COMPONENT REACTION; ADDITION-REACTIONS; PHASE SYNTHESIS

DOI:

10.1002/qsar.200540190

Web of Science ID:

ISI:000238548900002

Соавторы в МНС:

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Другие поля

Поле	Значение
Month	JUN
Publisher	WILEY-V C H VERLAG GMBH
Address	POSTFACH 101161, 69451 WEINHEIM, GERMANY
Language	English
EISSN	1611-0218
Keywords-Plus	DYNAMIC COMBINATORIAL CHEMISTRY; ORIENTED ORGANIC-SYNTHESIS; COMPONENT CONDENSATION REACTION; 3-COMPONENT REACTION; DIMETHYL ACETYLENEDICARBOXYLATE; CYCLOADDITION REACTIONS; HETEROCYCLIC-COMPOUNDS; 7-COMPONENT REACTION; ADDITION-REACTIONS; PHASE SYNTHESIS
Research-Areas	Pharmacology \& Pharmacy; Chemistry; Computer Science
Web-of-Science-Categories	Chemistry, Medicinal; Chemistry, Multidisciplinary; Computer Science, Interdisciplinary Applications; Pharmacology \& Pharmacy
Author-Email	mirma@htf.ustu.ru
Number-of-Cited-References	71
Usage-Count-Since-2013	10
Journal-ISO	QSAR Comb. Sci.
Doc-Delivery-Number	056TV