Reaction of CD117+ cells to renal lesion under conditions of phagocytic mononuclear system stimulation / Abidov M.T., Danilova I.G., Brykina I.A., Yushkov B.G., Pashnina I.A. // Bulletin of Experimental Biology and Medicine. - 2012. - V. 153, l. 1. - P. 61-63.

ISSN:

00074888

Type:

Article

Abstract:

The content of CD117+ cells in the kidneys and CD45 lowCD117+ cells in the bone marrow and blood of mice were studied after partial nephrectomy and under conditions of macrophage stimulation with 3-aminophthalhydrazide. The counts of tubular CD117+ epitheliocytes sharply increased and the content of CD45lowCD117 + cells in the bone marrow decreased after renal damage. Injection of 3-aminophthalhydrazide stimulated the expression of CD117 by renal epitheliocytes and led to reduction of CD45lowCD117+ cell counts in the bone marrow and blood. Macrophages stimulated proliferative processes in the kidney and differentiation of stem cells in the bone marrow due to synergic effects of their cytokines and stem cell factor. © 2012 Springer Science+Business Media, Inc.

Author keywords:

3-aminophthalhydrazide; kidneys; macrophages; regeneration

Index keywords:

luminol; stem cell factor receptor; animal cell; animal experiment; animal model; animal tissue; antigen expression; article; blood; bone marrow; CD117+ cell; cell count; cell differentiation; cell pr

DOI:

10.1007/s10517-012-1643-6

Смотреть в Scopus:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-84862766397&doi=10.1007%2fs10517-012-1643-6&partnerID=40&md5=1c96bea83fb5782a687eb6dd98c35d52

Соавторы в МНС:

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Другие поля

Поле	Значение
Link	https://www.scopus.com/inward/record.uri?eid=2-s2.0-84862766397&doi=10.1007%2fs10517-012-1643-6&partnerID=40&md5=1c96bea83fb5782a687eb6dd98c35d52
Affiliations	Institute of Immunology and Physiology, Ural Division of the Russian Academy of Sciences, Ekaterinburg, Russian Federation; Institute of Immunopathology, Moscow, Russian Federation
Author Keywords	3-aminophthalhydrazide; kidneys; macrophages; regeneration
Chemicals/CAS	luminol, 521-31-3; Antigens, CD45, 3.1.3.48; Luminol, 521-31-3; Proto-Oncogene Proteins c-kit, 2.7.10.1; isoluminol, 3682-14-2
References	Abidov, M.T., (2000) Byull. Eksp. Biol. Med., 3 (SUPPL.), pp. 11-19; Abidov, M.T., Karaulov, A.V., (2000) Byull. Eksp. Biol. Med., (SUPPL. NO. 3), pp. 7-10; Chereshnev, V.A., Yushkov, B.G., Abidov, M.T., (2004) Immunologiya, 25 (4), pp. 204-206; Yushkov, B.G., Danilova, I.G., Pashnina, I.A., (2010) Med. Immunol., 12 (12), pp. 7-12; Ema, H., Takano, H., Sudo, K., Nakauchi, H., (2000) J. Exp. Med., 192 (9), pp. 1281-1288. , 11067877 10.1084/jem.192.9.1281 1:CAS:528:DC%2BD3cXnvFWgt7g%3D; Miliaras, D., Karasavvidou, F., Papanikolaou, A., Sioutopoulou, D., (2004) J. Clin. Pathol., 57 (5), pp. 463-466. , 15113851 10.1136/jcp.2003.013532 1:CAS:528:DC%2BD2cXmtl2quro%3D; Ren, X., Hu, B., Colletti, L., (2008) Surgery, 143 (6), pp. 790-802. , 18549896 10.1016/j.surg.2008.03.021; Ricardo, S.D., Van Goor, H., Eddy, A.A., (2008) J. Clin. Invest., 118 (11), pp. 3522-3530. , 18982158 10.1172/JCI36150 1:CAS:528:DC%2BD1cXhtlGltLrP
Correspondence Address	Danilova, I.G.; Institute of Immunology and Physiology, Ural Division of the Russian Academy of Sciences, Ekaterinburg, Russian Federation; email: ig-danilova@yandex.ru
CODEN	BEXBA
PubMed ID	22808495
Language of Original Document	English
Abbreviated Source Title	Bull. Exp. Biol. Med.
Source	Scopus