Hemoglobin heterogeniety under conditions of abnormal erythropoiesis / Sumin M.N., Rezaikin A.V., Yushkov B.G. // Bulletin of Experimental Biology and Medicine. - 2003. - V. 135, l. 6. - P. 563-565.

ISSN:

00074888

Type:

Article

Abstract:

Experiments on rats showed that changes in the hemoglobin profile during hypoxia are determined by switching of erythropoiesis from the "basic" to "emergency" mode. The "basic" mode of erythropoiesis is typical of the mature organism under normal conditions. The "reserve" or "emergency" mode is realized in fetuses, senile animals, and during hypoxia. This mode is characterized by production of large erythrocytes with high content of fetal hemoglobin.

Author keywords:

Ageing; Hemoglobin subtypes; Hyperoxia; Hypoxia; Modes of erythropoiesis

Index keywords:

hemoglobin; hemoglobin; isoprotein; animal cell; animal experiment; animal model; article; blood oxygenation; blood sampling; bone marrow cell; cell fractionation; cell heterogeneity; controlled study

DOI:

10.1023/A:1025477202093

Смотреть в Scopus:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0242552165&doi=10.1023%2fA%3a1025477202093&partnerID=40&md5=b6bbc0d90dcc6bc4a3b67988ad8c3686

Соавторы в МНС:

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Другие поля

Поле	Значение
Link	https://www.scopus.com/inward/record.uri?eid=2-s2.0-0242552165&doi=10.1023%2fA%3a1025477202093&partnerID=40&md5=b6bbc0d90dcc6bc4a3b67988ad8c3686
Affiliations	Inst. of Ecol./Genet. of Microorgan., Ural Division, Russian Academy of Sciences, Ekaterinburg, Russian Federation
Author Keywords	Ageing; Hemoglobin subtypes; Hyperoxia; Hypoxia; Modes of erythropoiesis
Chemicals/CAS	hemoglobin, 9008-02-0; Hemoglobins; Protein Isoforms
References	Borisyuk, M.V., (1983) Uspekhi Fiziol. Nauk, 14 (1), pp. 85-101; Zapadenyuk, I.P., Zapadenyuk, V.I., Zakharia, E.A., Zapadenyuk, B.V., (1983) Laboratory Animals. Breeding, Keeping, and Handling in Experiments, , Kiev; Statrodu, N.F., Nazarenko, V.I., (1987) Heterogeneous System of Hemoglobins, , Structure, Properties, Synthesis, and Functional Role, Kiev; Alter, B.P., (1979) Exp. Hematol., 7, pp. 200-209; Bosch, F.H., Werre, J.M., Roerdinkholder-Stoelwinder, B., (1992) Blood., 79 (1), pp. 254-260; Kleihauer, E., Tang, T.E., Betke, K., (1967) Acta Haematol., 38, pp. 264-272; Murphy, J.R., (1973) J. Lab. Clin. Med., (2), pp. 334-341; Stamatoyannopoulos, G., Veith, R., Galanello, R., Papayannopoulou, T., (1985) Ann. N.Y. Acad. Sci., 445, pp. 188-197; Steinberg, M.H., (1997) Semin. Hemoglobin., 34 (3), pp. 8-14
Correspondence Address	Sumin, M.N.; Inst. of Ecol./Genet. of Microorgan., Ural Division, Russian Academy of Sciences, Ekaterinburg, Russian Federation; email: sumin@horizon.e-burg.ru
CODEN	BEXBA
PubMed ID	12937674
Language of Original Document	English
Abbreviated Source Title	Bull. Exp. Biol. Med.
Source	Scopus