Principles in designing drugs, natural hemopoietic stimulators / Goldberg E.D., Dygai A.M., Agafonov V.I., Aksinenko S.G., Goldberg V.E., Zhdanov V.V., Litvinenko V.I., Lyubavina P.A., Matyash M.G., Novitsky E.V., Ryzhakov V.M., Simanina E.V., Khlusov I.A., Yushkov B.G. // Experimental and Clinical Pharmacology. - 1995. - V. 58, l. 1. - P. 3-7.

ISSN:

08692092

Type:

Short Survey

Abstract:

The paper outlines the principles in designing hemostimulators by using glycosamineglycans. Hemostimulating properties of the tested agents is likely to be primarily due to the presence of D-glucuronic acid in their structure. The homotypic mechanisms are largely responsible for all agents' effect in stimulating hemopoiesis. Thus, they all virtually activate the function of the hemopoiesis-inducing microenvironment. In addition, they directly or indirectly stimulate the processes of proliferation and differentiation of precursor cells of erythro- and granulomonocytopoiesis.

Author keywords:

Index keywords:

glucuronic acid; glycosaminoglycan; hemopoietic growth factor; drug design; drug development; drug structure; hematopoiesis; nonhuman; short survey

DOI:

нет данных

Смотреть в Scopus:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0029072421&partnerID=40&md5=2c2d42263525542b161500d17049623d

Соавторы в МНС:

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Другие поля

Поле	Значение
Link	https://www.scopus.com/inward/record.uri?eid=2-s2.0-0029072421&partnerID=40&md5=2c2d42263525542b161500d17049623d
Affiliations	Laboratory of Pathophysiology, Inst. Pharmacol., Tomsk Res. Center, Russian Academy of Medical Sciences, 3 Lenin Pr., Tomsk 634028, Russian Federation
Chemicals/CAS	glucuronic acid, 36116-79-7, 576-37-4, 6556-12-3
Correspondence Address	Dygai, A.M.; Laboratory of Pathophysiology, Inst. Pharmacol., Tomsk Res. Center, Russian Academy of Medical Sciences, 3 Lenin Pr., Tomsk 634028, Russian Federation
CODEN	EKFAE
Language of Original Document	Russian
Abbreviated Source Title	EXP. CLIN. PHARMACOL.
Source	Scopus