Mechanism of action of benzene on hematopoiesis (investigation of hematopoietic stem cells) / Frash V.N., Yushkov B.G., Karaulov A.V., Skuratov V.L. // Bulletin of Experimental Biology and Medicine. - 1976. - V. 82, l. 1. - P. 985-987.

ISSN:

00074888

Type:

Article

Abstract:

The effect of benzene on colony-forming activity of the bone marrow and spleen was studied in four groups of experiments. In benzene hypoplasia of hematopoiesis, fewer colony-forming units were found in the hematopoietic organs although there was no change in the distribution of their cell types. Incubation of normal bone marrow cells with benzene did not reduce the efficiency of colony formation. Injection of benzene into lethally irradiated mice after transplantation of a suspension of normal bone marrow cells into the animals caused a sharp decrease in colony production, with inhibition chiefly of the formation of granulocytic colonies. These observations suggest that during benzene poisoning the properties of the microenvironment of the hematopoietic stem cell are modified. © 1976 Plenum Publishing Corporation.

Author keywords:

action of benzene; hematopoiesis; hematopoietic stem cell

Index keywords:

benzene; bone marrow; bone marrow cell; drug intoxication; hematopoiesis; mouse; spleen; theoretical study

DOI:

10.1007/BF00789847

Смотреть в Scopus:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0017048315&doi=10.1007%2fBF00789847&partnerID=40&md5=eb2f76f2968b0a7138dd748905f73532

Соавторы в МНС:

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Другие поля

Поле	Значение
Link	https://www.scopus.com/inward/record.uri?eid=2-s2.0-0017048315&doi=10.1007%2fBF00789847&partnerID=40&md5=eb2f76f2968b0a7138dd748905f73532
Affiliations	Sverdlovsk Research Institute of Work Hygiene and Occupational Diseases, Russia
Author Keywords	action of benzene; hematopoiesis; hematopoietic stem cell
Chemicals/CAS	benzene, 71-43-2
References	B. V. Aleshin, Sh. A. Burshtein, and B. I. Chernyak, in: Alimentary-Toxic Aleukia [in Russian], Orenburg (1947), pp. 125–144; L. A. Zorina, “Chronic benzene poisoning”, Author's Abstract of Doctoral Dissertation, Moscow (1971); V. N. Frash, in: Experimental Investigations into the Mechanisms of Hematopoiesis [in Russian], Sverdlovsk (1971), pp. 125–130; Chertkov, I.L., Lemenova, L.N., Mendelevich, O.A., (1972) Probl. Gematol., 1, p. 3; Shvets, V.N., Seslavina, L.S., Shikhodyrov, V.V., (1972) Byull. Éksp. Biol. Med., 6, p. 89; Yastrebov, A.P., Frash, V.N., (1975) Pat. Fiziol., 2, p. 76; Bock, H.E., Wiede, K., (1930) Folia Haemat. (Leipzig), 42, p. 7; Caffrey, R.W., Everett, N.B., Riecke, W.O., (1966) Anat. Rec., 155, p. 41; Ferguson, T., Harvey, W.H., Hamilton, T.D., (1933) J. Hyg. (London), 33, p. 547; Saunders, E.F., Amato, D., Freedman, M.H., (1974) Blood, 44, p. 913; McCulloch, E.A., Siminovitch, L., Till, J.E., (1965) Blood, 26, p. 399; Morley, A., Blacke, J., (1974) Aust. J. Exp. Biol. Med. Sci., 52, p. 909; Schrenk, H.H., Yant, W.P., Pearce, S.J., (1941) J. Indust. Hyg., 23, p. 20; Steinberg, B., (1949) Blood, 4, p. 550
Correspondence Address	Frash, V.N.; Sverdlovsk Research Institute of Work Hygiene and Occupational DiseasesRussia
Publisher	Kluwer Academic Publishers-Plenum Publishers
CODEN	BEXBA
Language of Original Document	English
Abbreviated Source Title	Bull Exp Biol Med
Source	Scopus