Evaluation of Biodistribution of Functionalized Magnetic Core/Carbon-Shell Nanoparticles in Systemic Method of Administration / Yushkov B. G.,Artashyan O. S.,Medvedeva S. Yu.,Byzov I. V.,Uimin M. A.,Ermakov A. E.,Bykova M. Yu.,Petrova I. M. // BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE. - 2015. - V. 159, l. 4. - P. 498-501.

ISSN/EISSN:

0007-4888 / 1573-8221

Type:

Article

Abstract:

We studied new magnetic nanocomposites consisting of a core(Fe) and carbon-shell inert to biological media. Iron-carbon nanoparticles circulate in the bloodstream for several minutes and are primarily accumulated in the liver; less intensive accumulation was found in the spleen and minimum in the lungs, kidneys, and heart. Accumulation of nanoparticles in the liver leads to the development of destructive processes and is accompanied by activation of compensatory-adaptive mechanisms. In the liver and spleen, structural changes are mild and mainly relate to changes in the microvasculature. In 6 months, the total content of nanoparticles in all tissues decreased due to their elimination from the body and the structure of the organs returned to normal.

Author keywords:

iron-carbon nanoparticles; biodistribution

DOI:

10.1007/s10517-015-3002-x

Web of Science ID:

ISI:000361818700024

Соавторы в МНС:

Другие поля

Поле	Значение
Month	AUG
Publisher	SPRINGER
Address	233 SPRING ST, NEW YORK, NY 10013 USA
Language	English
EISSN	1573-8221
Research-Areas	Research \& Experimental Medicine
Web-of-Science-Categories	Medicine, Research \& Experimental
Author-Email	artashyan@inbox.ru
ResearcherID-Numbers	Uimin, Mikhail/K-1319-2013 Yermakov, Anatoly/J-5185-2013 Byzov, Ilya/J-7850-2013
ORCID-Numbers	Uimin, Mikhail/0000-0003-3906-8101 Yermakov, Anatoly/0000-0001-6466-7064 Byzov, Ilya/0000-0003-1940-4892
Number-of-Cited-References	10
Usage-Count-Last-180-days	2
Usage-Count-Since-2013	13
Journal-ISO	Bull. Exp. Biol. Med.
Doc-Delivery-Number	CS1IX