Reaction of CD117(+) Cells to Renal Lesion under Conditions of Phagocytic Mononuclear System Stimulation / Abidov M. T.,Danilova I. G.,Brykina I. A.,Yushkov B. G.,Pashnina I. A. // BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE. - 2012. - V. 153, l. 1. - P. 61-63.

ISSN/EISSN:

0007-4888 / нет данных

Type:

Article

Abstract:

The content of CD117(+) cells in the kidneys and CD45(low)CD117(+) cells in the bone marrow and blood of mice were studied after partial nephrectomy and under conditions of macrophage stimulation with 3-aminophthalhydrazide. The counts of tubular CD117(+) epitheliocytes sharply increased and the content of CD45(low)CD117(+) cells in the bone marrow decreased after renal damage. Injection of 3-aminophthalhydrazide stimulated the expression of CD117 by renal epitheliocytes and led to reduction of CD45(low)CD117(+) cell counts in the bone marrow and blood. Macrophages stimulated proliferative processes in the kidney and differentiation of stem cells in the bone marrow due to synergic effects of their cytokines and stem cell factor.

Author keywords:

macrophages; 3-aminophthalhydrazide; regeneration; kidneys KIT

DOI:

10.1007/s10517-012-1643-6

Web of Science ID:

ISI:000305517000017

Соавторы в МНС:

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Другие поля

Поле	Значение
Month	MAY
Publisher	SPRINGER
Address	233 SPRING ST, NEW YORK, NY 10013 USA
Language	English
Keywords-Plus	KIT
Research-Areas	Research \& Experimental Medicine
Web-of-Science-Categories	Medicine, Research \& Experimental
Author-Email	ig-danilova@yan-dex.ru
ResearcherID-Numbers	Danilova, Irina/A-7952-2015
Number-of-Cited-References	8
Usage-Count-Since-2013	4
Journal-ISO	Bull. Exp. Biol. Med.
Doc-Delivery-Number	962CN