Synthesis and Cytotoxic Activity of 1,2,3-Triazole Derivatives in Glioma Cell Cultures / Khazhieva I. S.,Glukhareva T. V.,El'tsov O. S.,Morzherin Yu. Yu.,Minin A. A.,Pozdina V. A.,Ulitko M. V. // PHARMACEUTICAL CHEMISTRY JOURNAL. - 2015. - V. 49, l. 5. - P. 296-300.

ISSN/EISSN:

0091-150X / 1573-9031

Type:

Article

Abstract:

A series of 1,2,3-triazole derivatives was prepared and their cytotoxic actions on glioma cell cultures were studied. Amethod for the synthesis of 1-R-5-methyl- (1) H-{[}1,2,3]triazole-4-carboxamides is presented, based on transformation of 4-acetyl-1-phenyl- (1) H-{[}1,2,3]-triazolate sodium using primary amine hydrochlorides.

Author keywords:

1,2,3-triazoles; diazo compounds; regrouping; biological activity; cytotoxicity; glioma; cell cultures; IC50 TOXICITY; DESIGN

DOI:

10.1007/s11094-015-1273-1

Web of Science ID:

ISI:000362951000003

Соавторы в МНС:

Другие поля

Поле	Значение
Month	AUG
Publisher	SPRINGER
Address	233 SPRING ST, NEW YORK, NY 10013 USA
Language	English
EISSN	1573-9031
Keywords-Plus	TOXICITY; DESIGN
Research-Areas	Pharmacology \& Pharmacy
Web-of-Science-Categories	Chemistry, Medicinal; Pharmacology \& Pharmacy
ResearcherID-Numbers	Morzherin, Yury/M-7420-2013 Glukhareva, Tatiana/A-4610-2016 Ulitko, Maria/R-1760-2016
ORCID-Numbers	Morzherin, Yury/0000-0002-1333-6676 Glukhareva, Tatiana/0000-0002-5231-9879 Ulitko, Maria/0000-0003-3193-2903
Funding-Acknowledgement	Russian Foundation for Basic Research {[}13-03-00137]
Funding-Text	This study was supported by the Russian Foundation for Basic Research (Grant No. 13-03-00137).
Number-of-Cited-References	16
Usage-Count-Last-180-days	1
Usage-Count-Since-2013	8
Journal-ISO	Pharm. Chem. J.
Doc-Delivery-Number	CT6VQ