Three-Component Synthesis of 7-Hydroxy-7-polyfluoroalkylhexahydroimidazo{[}1,2-a]pyridin-5(1H)-ones / Goryaeva Marina V.,Burgart Yanina V.,Kudyakova Yulia S.,Ezhikova Marina A.,Kodess Mikhail I.,Slepukhin Pavel A.,Saloutin Victor I. // EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. - 2015. - V. , l. 28. - P. 6306-6314.

ISSN/EISSN:

1434-193X / 1099-0690

Type:

Article

Abstract:

A new straightforward three-component approach to 7-hydroxy-7-(polyfluoroalkyl) hexahydroimidazo{[}1,2-a]pyridin-5(1H)-ones with high diastereoselectivity and regio-specificity was developed starting from commercially available 3-oxo esters, methyl ketones, and 1,2-ethanediamines. The scope of this cyclization and its plausible mechanism are reported.

Author keywords:

Multicomponent reactions; Cyclization; Nitrogen heterocycles; Fluorine; Ketones; Amines CONTAINING HETEROCYCLIC-COMPOUNDS; RING-CHAIN ISOMERISM; ONE-POT SYNTHESIS; FLUOROCARBON DERIVATIVES; MEDICINAL CHEMISTRY; 3-OXO ESTERS; FLUORINE; 2-AMINOPYRIDINES; NITROGEN; ANALOGS

DOI:

10.1002/ejoc.201500822

Web of Science ID:

ISI:000362747900021

Соавторы в МНС:

Другие поля

Поле	Значение
Month	OCT
Publisher	WILEY-V C H VERLAG GMBH
Address	POSTFACH 101161, 69451 WEINHEIM, GERMANY
Language	English
EISSN	1099-0690
Keywords-Plus	CONTAINING HETEROCYCLIC-COMPOUNDS; RING-CHAIN ISOMERISM; ONE-POT SYNTHESIS; FLUOROCARBON DERIVATIVES; MEDICINAL CHEMISTRY; 3-OXO ESTERS; FLUORINE; 2-AMINOPYRIDINES; NITROGEN; ANALOGS
Research-Areas	Chemistry
Web-of-Science-Categories	Chemistry, Organic
Author-Email	pmv@ios.uran.ru
ResearcherID-Numbers	Burgart, Yanina/T-8025-2017 Kudyakova, Yulia/J-7484-2016
ORCID-Numbers	Burgart, Yanina/0000-0001-6061-2410 Kudyakova, Yulia/0000-0003-0637-1606
Funding-Acknowledgement	Russian Foundation for Basic Research {[}13-03-00617]; State Program for Supporting of Leading Scientific School of the Russian Federation {[}3656.2014.3]
Funding-Text	This research was financially supported by Russian Foundation for Basic Research (grant number 13-03-00617) and by the State Program for Supporting of Leading Scientific School of the Russian Federation (grant number 3656.2014.3).
Number-of-Cited-References	82
Usage-Count-Since-2013	3
Journal-ISO	Eur. J. Org. Chem.
Doc-Delivery-Number	CT4AK