Synthesis of purine and 2-aminopurine conjugates bearing the fragments of heterocyclic amines at position 6 / Gruzdev Dmitry A.,Musiyak Vera V.,Chulakov Evgeny N.,Levit Galina L.,Krasnov Victor P. // CHEMISTRY OF HETEROCYCLIC COMPOUNDS. - 2015. - V. 51, l. 8. - P. 738-744.

ISSN/EISSN:

0009-3122 / 1573-8353

Type:

Article

Abstract:

A series of novel N-(purin-6-yl)- and N-(2-aminopurin-6-yl) derivatives of heterocyclic amines was synthesized. It was found that preferred preparative method for N-(purin-6-yl) derivatives of heterocyclic amines is interaction of 6-chloropurine with heterocyclic amines without any catalyst; whereas N-(2-aminopurin-6-yl) derivatives were obtained in the moderate-to-high yields while heating 2-amino-6-chloropurine and heterocyclic amines in water in the presence of sulfuric acid.

Author keywords:

2-amino-6-chloropurine; 6-chloropurine; aromatic nucleophilic substitution; catalysis; heterocyclic amines SOLVOLYTIC DECOMPOSITIONS; TRIFLUOROACETIC-ACID; NUCLEOSIDE ANALOGS; KINETIC RESOLUTION; KINASE INHIBITORS; HYDROLYSIS; MECHANISMS; LIBRARIES

DOI:

10.1007/s10593-015-1767-5

Web of Science ID:

ISI:000363271200008

Соавторы в МНС:

—

Другие поля

Поле	Значение
Month	AUG
Publisher	SPRINGER
Address	233 SPRING ST, NEW YORK, NY 10013 USA
Language	English
EISSN	1573-8353
Keywords-Plus	SOLVOLYTIC DECOMPOSITIONS; TRIFLUOROACETIC-ACID; NUCLEOSIDE ANALOGS; KINETIC RESOLUTION; KINASE INHIBITORS; HYDROLYSIS; MECHANISMS; LIBRARIES
Research-Areas	Chemistry
Web-of-Science-Categories	Chemistry, Organic
Author-Email	gruzdev-da@ios.uran.ru
Funding-Acknowledgement	Russian Science Fund {[}14-13-01077]
Funding-Text	This work was performed with financial support from the Russian Science Fund (grant 14-13-01077).
Number-of-Cited-References	38
Usage-Count-Last-180-days	1
Usage-Count-Since-2013	6
Journal-ISO	Chem. Heterocycl. Compds.
Doc-Delivery-Number	CU1HK