Identification and analytical characteristics of synthetic cannabinoids with an indazole-3-carboxamide structure bearing a N-1-methoxycarbonylalkyl group / Shevyrin V., Melkozerov V., Nevero A., Eltsov O., Shafran Y., Morzherin Y., Lebedev A.T. // Analytical and Bioanalytical Chemistry. - 2015. - V. 407, l. 21. - P. 6301-6315.

ISSN:
16182642
Type:
Article
Abstract:
Illicit new psychoactive substances (NPS) are a serious threat to health throughout the world. Such NPS do not usually pass preliminary pharmacological trials. In 2014, we identified a series of five new synthetic cannabinoids with an indazole-3-carboxamide structure bearing an N-1-methoxycarbonylalkyl group. The compounds have very high cannabimimetic activity which has caused mass severe intoxication and deaths. The compounds were identified by means of gas chromatography- mass spectrometry (GC-MS), including high-resolution mass spectrometry (GC-HRMS), ultrahigh- performance liquid chromatography-high-resolution tandem mass spectrometry (UHPLC-HRMS2), and 1H and 13C nuclear magnetic resonance spectroscopy (NMR). The peculiarities of mass-spectral fragmentation of the compounds after electron ionization (EI) ionization and collision-induced dissociation (CID) were studied. The analytical characteristics reported for the compounds will enable their identification in a variety of materials seized from criminals. © Springer Science+Business Media Dordrecht 2015.
Author keywords:
Chromatography; High-resolution mass spectrometry; Indazole-3-carboxamides; New psychoactive substances; NMR; Synthetic cannabinoids
Index keywords:
Chromatography; Gas chromatography; Health risks; High performance liquid chromatography; Ionization; Ionization of gases; Liquid chromatography; Magnetic resonance spectroscopy; Mass spectrometry; Nu
DOI:
10.1007/s00216-015-8612-7
Смотреть в Scopus:
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Link https://www.scopus.com/inward/record.uri?eid=2-s2.0-84943198498&doi=10.1007%2fs00216-015-8612-7&partnerID=40&md5=b88cb994a9f3b1c56f5f310a1f7b4538
Affiliations Institute of Chemistry and Technology, Ural Federal University, 19 Mira Str., Ekaterinburg, Russian Federation; Expert and Criminalistic Center, Main Agency of the Ministry of the Interior of the Russian Federation, Sverdlovsk Region Branch, 17 Lenina Avenue, Ekaterinburg, Russian Federation; State Committee of Forensic Expertise of Republic of Belarus, 43 Kalvariyskaya Str., Minsk, Belarus; TOSLab. Ltd., Bldg. 1, 5 Initsiativnaia Str., Moscow, Russian Federation; Organic Chemistry Department, Lomonosov Moscow State University, Leninskie Gory 1/3, Moscow, Russian Federation
Author Keywords Chromatography; High-resolution mass spectrometry; Indazole-3-carboxamides; New psychoactive substances; NMR; Synthetic cannabinoids
Chemicals/CAS Cannabinoids; Carboxylic Acids; Indazoles
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Correspondence Address Lebedev, A.T.; Organic Chemistry Department, Lomonosov Moscow State University, Leninskie Gory 1/3, Russian Federation; email: a.lebedev@org.chem.msu.ru
Publisher Springer Verlag
CODEN ABCNB
PubMed ID 25893797
Language of Original Document English
Abbreviated Source Title Anal. Bioanal. Chem.
Source Scopus