Synthesis of New 1,3,4-Thiadiazines Capable of Inhibiting Nonenzymatic Glycosylation of Proteins / Sidorova L. P.,Tseitler T. A.,Perova N. M.,Emel'yanov V. V.,Savateeva E. A.,Maksimova N. E.,Mochul'skaya N. N.,Chereshnev V. A.,Chupakhin O. N. // PHARMACEUTICAL CHEMISTRY JOURNAL. - 2015. - V. 49, l. 8. - P. 501-505.

ISSN/EISSN:

0091-150X / 1573-9031

Type:

Article

Abstract:

A series of new 1,3,4-thiadiazines with cycloalkylamino (cyclopropylamino, cyclobutylamino, cyclopentylamino, cyclohexylamino) groups were synthesized via cyclocondensation of alpha-haloacetophenones with thiosemicarbazides containing 4-cycloalkyl groups. Five of the synthesized compounds showed the capability to inhibit nonenzymatic glycosylation of proteins in vitro in a model system. The obtained test results allowed compounds containing cyclopropylamino residues (LT-1a and LT-1d) to be recommended for further in vivo testing.

Author keywords:

1,3,4-thiadiazine; cyclocondensation; alpha-haloacetophenones; thiosemicarbazides; nonenzymatic glycosylation of proteins PREVENTION

DOI:

10.1007/s11094-015-1314-9

Web of Science ID:

ISI:000365510500002

Соавторы в МНС:

Другие поля

Поле	Значение
Month	NOV
Publisher	SPRINGER
Address	233 SPRING ST, NEW YORK, NY 10013 USA
Language	English
EISSN	1573-9031
Keywords-Plus	PREVENTION
Research-Areas	Pharmacology \& Pharmacy
Web-of-Science-Categories	Chemistry, Medicinal; Pharmacology \& Pharmacy
Author-Email	vlapp@isnet.ru v.chereshnev@iip.uran.ru
ResearcherID-Numbers	Chereshnev, Valerii/P-7704-2017 Chereshnev, Valeriy/Q-1730-2015
ORCID-Numbers	Chereshnev, Valerii/0000-0003-4329-147X
Number-of-Cited-References	12
Usage-Count-Last-180-days	3
Usage-Count-Since-2013	13
Journal-ISO	Pharm. Chem. J.
Doc-Delivery-Number	CX2FF