Some patterns of metallic nanoparticles' combined subchronic toxicity as exemplified by a combination of nickel and manganese oxide nanoparticles / Katsnelson B.A., Minigaliyeva I.A., Panov V.G., Privalova L.I., Varaksin A.N., Gurvich V.B., Sutunkova M.P., Shur V.Y., Shishkina E.V., Valamina I.E., Makeyev O.H. // Food and Chemical Toxicology. - 2015. - V. 86, l. . - P. 351-364.

ISSN:
02786915
Type:
Article
Abstract:
Stable suspensions of NiO and/or Mn3O4 nanoparticles with a mean diameter of 16.7 ± 8.2 nm and 18.4 ± 5.4 nm, respectively, prepared by laser ablation of 99.99% pure metals in de-ionized water were repeatedly injected IP to rats at a dose of 0.50 mg or 0.25 mg 3 times a week up to 18 injections, either separately or in different combinations. Many functional indices as well as histological features of the liver, spleen, kidneys and brain were evaluated for signs of toxicity. The accumulation of Ni and Mn in these organs was measured with the help of AES and EPR methods. Both metallic nanoparticles proved adversely bio-active, but those of Mn3O4 were found to be more noxious in most of the non-specific toxicity manifestations. Moreover, they induced a more marked damaging effect in the neurons of the caudate nucleus and hippocampus which may be considered an experimental correlate of manganese-induced parkinsonism. Mathematical analysis based on the Response Surface Methodology (RSM) revealed a diversity of combined toxicity types depending not only on particular effects these types are assessed for but on their level as well. The prognostic power of the RSM model proved satisfactory. © 2015 Elsevier Ltd.
Author keywords:
Manganese (II,III) oxide; Mathematical analysis of combined action; Nanoparticles; Nickel (II) oxide; Subchronic toxicity
Index keywords:
manganese oxide nanoparticle; metallic nanoparticle; nanoparticle; nickel nanoparticle; unclassified drug; manganese derivative; manganese oxide; metal nanoparticle; nickel; nickel monoxide; oxide; ad
DOI:
10.1016/j.fct.2015.11.012
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-84947908932&doi=10.1016%2fj.fct.2015.11.012&partnerID=40&md5=d0da1a3260d0bc2b3cfd9876dd7d5ffe
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Affiliations The Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, Ekaterinburg, Russian Federation; Institute of Industrial Ecology, The Urals Branch of the Russian Academy of Sciences, Ekaterinburg, Russian Federation; The Institute of Natural Sciences, The Ural Federal University, Ekaterinburg, Russian Federation; The Central Research Laboratory of the Ural Medical University, Ekaterinburg, Russian Federation
Author Keywords Manganese (II,III) oxide; Mathematical analysis of combined action; Nanoparticles; Nickel (II) oxide; Subchronic toxicity
Chemicals/CAS manganese oxide, 11129-60-5, 1317-35-7; nickel, 7440-02-0; oxide, 16833-27-5; Manganese Compounds; manganese oxide; Nickel; nickel monoxide; Oxides
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Correspondence Address Katsnelson, B.A.30 Popov Str, Russian Federation; email: bkaznelson@etel.ru
Publisher Elsevier Ltd
CODEN FCTOD
PubMed ID 26607108
Language of Original Document English
Abbreviated Source Title Food Chem. Toxicol.
Source Scopus