Synthesis and Cytotoxic Activity of 1,2,3-Triazole Derivatives in Glioma Cell Cultures / Khazhieva I.S., Glukhareva T.V., El’tsov O.S., Morzherin Y.Y., Minin A.A., Pozdina V.A., Ulitko M.V. // Pharmaceutical Chemistry Journal. - 2015. - V. 49, l. 5. - P. 296-300.

ISSN:

0091150X

Type:

Article

Abstract:

A series of 1,2,3-triazole derivatives was prepared and their cytotoxic actions on glioma cell cultures were studied. Amethod for the synthesis of 1-R-5-methyl-1H-[1,2,3]triazole-4-carboxamides is presented, based on transformation of 4-acetyl-1-phenyl-1H-[1,2,3]-triazolate sodium using primary amine hydrochlorides. © 2015, Springer Science+Business Media New York.

Author keywords:

1,2,3-triazoles; biological activity; cell cultures; cytotoxicity; diazo compounds; glioma; IC50; regrouping

Index keywords:

(4 methylphenyl) 5 methyl 1h[1,2,3]triazole 4 carboxylic acid anilide; 1 benzyl 5 methyl 1h [1,2,3]triazole 4 carboxylic acid anilide; 1 methoxy 5 methyl 1h [1,2,3]triazole 4 carboxylic acid anilide;

DOI:

10.1007/s11094-015-1273-1

Смотреть в Scopus:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-84951908701&doi=10.1007%2fs11094-015-1273-1&partnerID=40&md5=9a0b8a6b7d6b3d31fe238770110518f3

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Другие поля

Поле	Значение
Link	https://www.scopus.com/inward/record.uri?eid=2-s2.0-84951908701&doi=10.1007%2fs11094-015-1273-1&partnerID=40&md5=9a0b8a6b7d6b3d31fe238770110518f3
Affiliations	First President of Russia B. N. El’tsin Urals Federal University, Ekaterinburg, Russian Federation
Author Keywords	1,2,3-triazoles; biological activity; cell cultures; cytotoxicity; diazo compounds; glioma; IC50; regrouping
Chemicals/CAS	1,2,3 triazole derivative, 53897-99-7
Funding Details	13-03-00137, RFBR, Russian Foundation for Basic Research
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Correspondence Address	Khazhieva, I.S.; First President of Russia B. N. El’tsin Urals Federal UniversityRussian Federation
Publisher	Springer New York LLC
CODEN	PCJOA
Language of Original Document	English
Abbreviated Source Title	Pharm. Chem. J.
Source	Scopus