Synthesis, crystal structure and biological activity of N-cyanosulfoximine derivative containing 1,2,3-thiadiazole / Mao W.-T., Zong G.-N., Fan Z.-J., Li F.-Y., Song H.-B., Li J.-J., Tatiana K.A., Inna K., Ksenia L., Yury M.Y., Nataliya B.P. // Jiegou Huaxue. - 2015. - V. 34, l. 9. - P. 1428-1433.

ISSN:
02545861
Type:
Article
Abstract:
The title compound N-cyanosulfoximine derivative containing 1,2,3-thiadiazole (C6H8N4OS2, Mr = 216.28) has been synthesized using 4-(chloromethyl)-5-methyl-1,2,3-thiadiazole as the starting material, and its structure was characterized by IR, 1H NMR, HRMS, elemental analysis and single-crystal X-ray diffraction. The crystal of the title compound belongs to orthorhombic, space group Pna21 with a = 14.730(6), b = 5.478(2), c = 22.619(9) A, Z = 8, V = 1825.0(13) A3, Dc = 1.574 g/cm3, β = 0.547 mm-1, F(000) = 896, R = 0.0767 and wR (I > 2σ(I)) = 0.2064. X-ray analysis indicates that in this crystal double enantiomers are found as the basically asymmetrical unit and interactions between S(1)⋯N(3), S(3)⋯N(4) and S(3)⋯N(7) are observed. This kind of interactions extends the molecules into a one-dimensional double chain. The preliminary biological test showed that the title compound had insecticidal activity against Myzus persicae in a certain degree and also presented moderate potential bioactivity against tobacco mosaic virus (TMV).
Author keywords:
1,2,3-thiadiazole; Biological activity; Crystal structure; Sulfoximine; Synthesis
Index keywords:
нет данных
DOI:
10.14102/j.cnki.0254-5861.2011
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-84942757861&doi=10.14102%2fj.cnki.0254-5861.2011-0665&partnerID=40&md5=508e31ef027ae2b3f7e87f237fdc75dd
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Link https://www.scopus.com/inward/record.uri?eid=2-s2.0-84942757861&doi=10.14102%2fj.cnki.0254-5861.2011-0665&partnerID=40&md5=508e31ef027ae2b3f7e87f237fdc75dd
Affiliations State Key Laboratory of Elemento-Organic Chemistry, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, Tianjin, China; College of Chemistry and Pharmacy Engineering, Nanyang Normal University, Henan, China; Ural Federal University Named after the First President of Russia B. N. Yeltsin, Yeltsin UrFU, Ekaterinburg, Russian Federation
Author Keywords 1,2,3-thiadiazole; Biological activity; Crystal structure; Sulfoximine; Synthesis
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Correspondence Address Fan, Z.-J.; State Key Laboratory of Elemento-Organic Chemistry, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai UniversityChina
Publisher Fujian Institute of Research of the Structure of Matter
Language of Original Document English
Abbreviated Source Title Jiegou Huaxue
Source Scopus