The technique for receiving vascular autoprostheses for angioplasty / Yushkov B., Tyumentseva N., Khodakov V., Medvedeva S., Krokhin D., Plaksin K., Rantsev M., Sarapultsev P., Sarapultsev A. // Gazzetta Medica Italiana Archivio per le Scienze Mediche. - 2015. - V. 174, l. 1-2. - P. 23-31.

ISSN:

03933660

Type:

Article

Abstract:

Aim. The objective of this research was to develop the technique of receiving connective-tissue autoprostheses and to assess their performance characteristics after they have been auto-transplanted into arterial vessels. Methods. The 5-week old connective-tissue prostheses were used for plastic repair of carotid arteries and femoral arteries of rats and rabbits, respectively, which served as the source body for building these prostheses. The prostheses were sewn end-to-end into the transected vessel. The ultrasonic and angiographic examinations showed that the prostheses remained patent and manifested normal functions 3 and 6 months after the surgery. No signs of thrombosis or occlusion were detected, which is confirmed by the histological analyses. The electronic microscopy indicated that endothelial cells started to develop on the inner surface of the autoprostheses. Results. The experiments performed on rats and rabbits have shown the possibility of development of a connective-tissue prosthesis on the PVC scaffold inserted under the skin. The development goes through gradual thinning of the wall, formation of fibrous connective tissue and arrangement of collagen fibers, reduction in the number of cells per unit area and predominance of more mature fibrocyte cells. Conclusion. The performed experimental research shows that connective-tissue prostheses can be built in animals both with the underdeveloped and with the well-defined subcutaneous fat layer. The autoprostheses received under the proposed technique feature biological inertia and good plastic characteristics; they are thrombosis-resistant and sufficiently strong.

Author keywords:

Angioplasty; Prostheses and implants; Rats; Vascular surgical procedures

Index keywords:

angioplasty; animal experiment; Article; carotid artery; collagen fiber; connective tissue prosthesis; femoral artery; nonhuman; prosthesis; rabbit; rat; tensile strength; vascular endothelium

DOI:

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Link	https://www.scopus.com/inward/record.uri?eid=2-s2.0-84946558412&partnerID=40&md5=799a228a4eeb1721b6e7eb4fed4f4154
Affiliations	Fed. State Autonomous Educ. Inst. of Higher Prof. Educ. Ural Fed. Univ. Named After the First Pres. of Russ. B.N. Yeltsin, Ekaterinburg, Russian Federation; Institute of Immunology and Physiology (IIP), Ural Division of Russian Academy of Sciences, 106 Pervomaiskaya Str., Ekaterinburg, Russian Federation; Department of General Surgery, Ural State Medical University, Ekaterinburg, Russian Federation
Author Keywords	Angioplasty; Prostheses and implants; Rats; Vascular surgical procedures
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Correspondence Address	Sarapultsev, A.; Institute of Immunology and Physiology (IIP), Ural Division of Russian Academy of Sciences, 106 Pervomaiskaya Str., Russian Federation
Publisher	Edizioni Minerva Medica
CODEN	GMIME
Language of Original Document	English
Abbreviated Source Title	Gazz. Med. Ital. Arch. Sci. Med.
Source	Scopus