Effects of Acute Myocardial Ischemia in Mathematical Models of Heterogeneous Myocardium / Vasilyeva Anastasia,Vikulova Nathalie,Solovyova Olga,Markhasin Vladimir S. // . - 2014. - V. 41, l. . - P. 881-884.

ISSN/EISSN:

0276-6574 / нет данных

Type:

Proceedings Paper

Abstract:

It has been shown that isolated sub-epicardial (EPI) and sub-endocardial (ENDO) myocytes have distinct electrical and mechanical properties in normal heart ventricle and differently respond to interventions. We utilized our electromechanical models of EPI and ENDO myocytes to simulate their responses to the acute ischemia and to predict effects of cell electromechanical coupling within a heterogeneous 1D tissue model. Intracellular effects of acute ischemia were simulated via a combination of two hypoxic consequences - a time-dependent increase in {[}K+](o) and a reduction in {[}ATP](i) which affected the activity of ATP-sensitive and other potassium channels. In cellular models we showed that the higher sensitivity of ATP - sensitive potassium currents provided for a greater action potential (AP) shortening and force decrease in EPI versus EN DO cells under hypoxia. In a ID heterogeneous myocardial strand comprising segments of EPI, ENDO and intermediate cell type, the hypoxic consequences also resulted in a decrease in the force production, while the dispersion of repolarisation between the coupled cells increased significantly above the difference in AP duration in uncoupled cells. Our modeling results suggest significant increase in the transmural electrical and mechanical heterogeneity between isolated cells under hypoxia, which further increases due to cell interactions within the tissue creating substrate for arrhythmia.

Author keywords:

VENTRICLE; RESPONSES; CHANNELS

DOI:

нет данных

Web of Science ID:

ISI:000370068300222

Соавторы в МНС:

Другие поля

Поле	Значение
Editor	Murray, A
Booktitle	2014 COMPUTING IN CARDIOLOGY CONFERENCE (CINC), VOL 41
Series	Computing in Cardiology Series
Note	41st Computing in Cardiology Conference (CinC), Cambridge, MA, SEP 07-10, 2014
Organization	Massachusetts Inst Technol; European Soc Cardiol; IEEE EMBS; Mortara; PhysioNet; Philips; Mindray; IBM; Zoll; Mitsubishi Elect; lOP Publishing; IMES; CSAIL; Medtronic; Boston Sci; Samsung; GE
Publisher	IEEE
Address	345 E 47TH ST, NEW YORK, NY 10017 USA
Language	English
ISBN	978-1-4799-4346-3
Keywords-Plus	VENTRICLE; RESPONSES; CHANNELS
Research-Areas	Cardiovascular System \& Cardiology; Computer Science; Mathematical \& Computational Biology
Web-of-Science-Categories	Cardiac \& Cardiovascular Systems; Computer Science, Interdisciplinary Applications; Mathematical \& Computational Biology
Author-Email	a.vasilyeva@iip.uran.ru
ResearcherID-Numbers	Solovyova, Olga/T-8232-2017 Balakina-Vikulova, Nathalie/D-9833-2015
ORCID-Numbers	Balakina-Vikulova, Nathalie/0000-0003-1316-4437
Number-of-Cited-References	10
Usage-Count-Last-180-days	1
Usage-Count-Since-2013	1
Doc-Delivery-Number	BE2TW