Evaluation of Biodistribution of Functionalized Magnetic Core/Carbon-Shell Nanoparticles in Systemic Method of Administration / Yushkov B.G., Artashyan O.S., Medvedeva S.Y., Byzov I.V., Uimin M.A., Ermakov A.E., Bykova M.Y., Petrova I.M. // Bulletin of Experimental Biology and Medicine. - 2015. - V. 159, l. 4. - P. 498-501.

ISSN:

00074888

Type:

Article

Abstract:

We studied new magnetic nanocomposites consisting of a core(Fe) and carbon-shell inert to biological media. Iron-carbon nanoparticles circulate in the bloodstream for several minutes and are primarily accumulated in the liver; less intensive accumulation was found in the spleen and minimum in the lungs, kidneys, and heart. Accumulation of nanoparticles in the liver leads to the development of destructive processes and is accompanied by activation of compensatory-adaptive mechanisms. In the liver and spleen, structural changes are mild and mainly relate to changes in the microvasculature. In 6 months, the total content of nanoparticles in all tissues decreased due to their elimination from the body and the structure of the organs returned to normal. © 2015, Springer Science+Business Media New York.

Author keywords:

biodistribution; iron-carbon nanoparticles

Index keywords:

carbon nanoparticle; iron nanoparticle; nanocomposite; nanoshell; drug carrier; magnetite nanoparticle; nanocomposite; animal cell; animal tissue; Article; bioaccumulation; concentration (parameters);

DOI:

10.1007/s10517-015-3002-x

Смотреть в Scopus:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-84957845902&doi=10.1007%2fs10517-015-3002-x&partnerID=40&md5=b6a2ae0a963a9aea83e3af100c2cfed3

Соавторы в МНС:

Другие поля

Поле	Значение
Link	https://www.scopus.com/inward/record.uri?eid=2-s2.0-84957845902&doi=10.1007%2fs10517-015-3002-x&partnerID=40&md5=b6a2ae0a963a9aea83e3af100c2cfed3
Affiliations	Institute of Immunology and Physiology, Ural Division of Russian Academy of Sciences, Ekaterinburg, Russian Federation; Ural Federal University n. a. First President of Russia B. N. Yeltsin, Ekaterinburg, Russian Federation; Institute of Metal Physics, Ural Division of Russian Academy of Sciences, Ekaterinburg, Russian Federation
Author Keywords	biodistribution; iron-carbon nanoparticles
Chemicals/CAS	Drug Carriers; Magnetite Nanoparticles
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Correspondence Address	Artashyan, O.S.; Institute of Immunology and Physiology, Ural Division of Russian Academy of SciencesRussian Federation; email: artashyan@inbox.ru
Publisher	Springer New York LLC
CODEN	BEXBA
PubMed ID	26395633
Language of Original Document	English
Abbreviated Source Title	Bull. Exp. Biol. Med.
Source	Scopus