Synthesis of pyrido{[}2,3-d]pyrimidines from 6-amino-1,3-dimethyluracil and aldehydes / Azev Yu. A.,Ermakova O. S.,Gibor A. M.,Bakulev V. A.,Ezhikova M. A.,Kodess M. I. // RUSSIAN JOURNAL OF ORGANIC CHEMISTRY. - 2015. - V. 51, l. 12. - P. 1784-1787.

ISSN/EISSN:

1070-4280 / 1608-3393

Type:

Article

Abstract:

6-Amino-1,3-dimethyluracil reacted with aliphatic aldehydes on heating in formic acid to give mixtures of 1,3,7,9-tetramethylpyrido{[}2,3-d: 6,5-d']dipyrimidine-2,4,6,8(1H,3H,7H,9H)-tetraone and the corresponding 5,6-dialkyl-1,3-dimethylpyrido{[}2,3-d]pyrimidine-2,4(1H,3H)-diones. The reaction of 6-amino-1,3-dimethyluracil with 3-phenylprop-2-enal under analogous conditions afforded 6-benzyl-1,3-dimethyl-5-{[}(E)-2-phenylvinyl]pyrido{[}2,3-d]pyrimidine-2 ,4(1H,3H)-dione and 1,3-dimethyl-5-phenylpyrido{[}2,3-d]pyrimidine-2,4(1H,3H)-dione. 1,3-Dimethyl-7-phenylpyrido{[}2,3-d]pyrimidine-2,4(1H,3H)-dione was obtained in the reaction of the title compound with 3-phenylpropynaldehyde diethyl acetal.

Author keywords:

нет данных

DOI:

10.1134/S1070428015120210

Web of Science ID:

ISI:000368737400021

Соавторы в МНС:

Другие поля

Поле	Значение
Month	DEC
Publisher	MAIK NAUKA/INTERPERIODICA/SPRINGER
Address	233 SPRING ST, NEW YORK, NY 10013-1578 USA
Language	English
EISSN	1608-3393
Research-Areas	Chemistry
Web-of-Science-Categories	Chemistry, Organic
Author-Email	azural@yandex.ru
Funding-Acknowledgement	Russian Foundation for Basic Research {[}14-03-01033]; Ministry of Education and Science of the Russian Federation {[}4.1626.2014/K]
Funding-Text	This work was performed under financial support by the Russian Foundation for Basic Research (project no. 14-03-01033) and by the Ministry of Education and Science of the Russian Federation (state contract no. 4.1626.2014/K).
Number-of-Cited-References	10
Usage-Count-Last-180-days	1
Usage-Count-Since-2013	7
Journal-ISO	Russ. J. Organ. Chem.
Doc-Delivery-Number	DB7ZY