Synthesis and biological activities of novel 2-amino-1,3-thiazole-4-carboxylic acid derivatives / Li Feng-Yun,Guo Xiao-Feng,Fan Zhi-Jin,Zhang Yu-Qing,Zong Guang-Ning,Qian Xiao-Lin,Ma Liu-Yong,Chen Lai,Zhu Yu-Jie,Tatiana Kalinina,Morzherin Yury Yu.,Belskaya Nataliya P. // CHINESE CHEMICAL LETTERS. - 2015. - V. 26, l. 10. - P. 1315-1318.

ISSN/EISSN:

1001-8417 / 1878-5964

Type:

Article

Abstract:

A series of novel 2-amino-1,3-thiazole-4-carboxylic acid derivatives were designed and synthesized. Their structures were confirmed by melting points, IR, H-1 NMR, C-13 NMR, and HRMS or elemental analysis. Biological activities of all title compounds including fungicidal activity and antivirus activity were evaluated systematically. Preliminary bioassays indicated that these compounds exhibited good fungicidal activity at 50 mu g/mL, compounds 4b and 4i exhibited over 50\% activity against six fungi tested. Most compounds showed good activity against TMV with different models in vivo at 100 mu g/mL. Compounds 4c and 4e stood out with high effects against TMV in vivo in all models tested, including protective, inactivative, curative, and inductive activities. These data demonstrate a new strategy for fungi and virus control. (C) 2015 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.

Author keywords:

1,3-Thiazole derivatives; Fungicidal activity; Anti-TMV activity 1,2,3-THIADIAZOLE DERIVATIVES; RESISTANCE; INHIBITORS; DESIGN

DOI:

10.1016/j.cclet.2015.05.040

Web of Science ID:

ISI:000364253800026

Соавторы в МНС:

Другие поля

Поле	Значение
Month	OCT
Publisher	ELSEVIER SCIENCE INC
Address	360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
Language	English
EISSN	1878-5964
Keywords-Plus	1,2,3-THIADIAZOLE DERIVATIVES; RESISTANCE; INHIBITORS; DESIGN
Research-Areas	Chemistry
Web-of-Science-Categories	Chemistry, Multidisciplinary
Author-Email	fanzj@nankai.edu.cn n.p.belskaya@urfu.ru
ResearcherID-Numbers	Belskaya, Nataliya/S-3953-2017 Morzherin, Yury/M-7420-2013
ORCID-Numbers	Belskaya, Nataliya/0000-0002-2509-7916 Morzherin, Yury/0000-0002-1333-6676
Funding-Acknowledgement	International Science \& Technology Cooperation Program of China {[}2014DFR41030]
Funding-Text	This work was partially supported by The International Science \& Technology Cooperation Program of China (No. 2014DFR41030). Nataliya P. Belskaya thanks Russian State Task of Ministry Education and Science (No. 4.560.2014/K). Kalinina Tatiana thanks RFBF (No. 13-03-00137).
Number-of-Cited-References	23
Usage-Count-Last-180-days	2
Usage-Count-Since-2013	13
Journal-ISO	Chin. Chem. Lett.
Doc-Delivery-Number	CV4RI