TRIAZENES - REACTIVITY AND MECHANISM OF ACTION .12. RELATIONSHIP BETWEEN THE STRUCTURE, REACTIVITY, AND CYTOTOXIC ACTIVITY IN AROMATIC SALTS OF DIAZONIUM / NIFONTOV VI,BELSKAYA NP,KRUPNOVA LV,BARYBIN AS // KHIMIKO-FARMATSEVTICHESKII ZHURNAL. - 1992. - V. 26, l. 7-8. - P. 18-21.

ISSN/EISSN:

0023-1134 / нет данных

Type:

Article

Abstract:

This paper summaries the findings to establish the relationship between the structure, reactivity in neutral (biological) environments and the cytotoxic activity of aromatic diazonium salts (ADS) as an active triazenes and to outline the prospects for goal-oriented search for new biologically active substances. To define the reaction rate ratios of C-, S- and N-azocombination of ADS in the neutral (biological) media as C-, S,- and N-nucleophils, in addition to free amino acids, the authors used amino acid derivatives simulating the reactivity of the phenol cycle of tyrosine, the imidazole nucleus of histidine, N(alpha)-, N(epsilon)- and SH-groups of amino acids as part of proteins and peptides.

Author keywords:

нет данных

DOI:

нет данных

Web of Science ID:

ISI:A1992NW63500004

Соавторы в МНС:

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Другие поля

Поле	Значение
Month	JUL-AUG
Publisher	IZD VO MEDITSINA
Address	PETROVERIGSKII PER 6-8, K-142 MOSCOW, RUSSIA
Language	Russian
Research-Areas	Pharmacology \& Pharmacy
Web-of-Science-Categories	Pharmacology \& Pharmacy
ResearcherID-Numbers	Belskaya, Nataliya/S-3953-2017
ORCID-Numbers	Belskaya, Nataliya/0000-0002-2509-7916
Number-of-Cited-References	12
Usage-Count-Last-180-days	1
Usage-Count-Since-2013	2
Doc-Delivery-Number	NW635