MOLECULAR MECHANISM OF ACTION OF ANTIVIRAL ADAMANTANE AGENTS / KISELEV OI,BLINOV VM,KOZELETSKAYA KN,ILYENKO VI,PLATONOV VG,CHUPAKHIN ON,STUKOVA MA,KARGINOV VA // VESTNIK ROSSIISKOI AKADEMII MEDITSINSKIKH NAUK. - 1993. - V. , l. 3. - P. 10-15.

ISSN/EISSN:

0869-6047 / нет данных

Type:

Article

Abstract:

Regions of possible interaction between remantadine and transmebrane M2 protein are revealed by analysis of amino acid substitutions in remantadine- and deutiforin-resistant influenza viruses. The major region includes 5-6 amino acid residues at position 25-31, partially involving the premembrane region and the first position of a hydrophobic membrane-associated domain. The proposed model action of remantadine and its derivatives suggests that remantadine is included into the cell membrane lipid bimolecular layer by its adamantane share and its positively charged NH2-group is exposed to the cell surface. This allows remantadine and its analogs to be regarded as molecular `'hindrances'' for viral particle decapsidation and budding.

Author keywords:

INFLUENZA-A VIRUSES; ENVELOPED VIRUSES; M-PROTEIN; AMANTADINE; RIMANTADINE; RESISTANCE; FUSION; ENTRY; CELLS

DOI:

нет данных

Web of Science ID:

ISI:A1993MK74200003

Соавторы в МНС:

—

Другие поля

Поле	Значение
Publisher	IZD VO MEDITSINA
Address	PETROVERIGSKII PER 6-8, K-142 MOSCOW, RUSSIA
Language	Russian
Keywords-Plus	INFLUENZA-A VIRUSES; ENVELOPED VIRUSES; M-PROTEIN; AMANTADINE; RIMANTADINE; RESISTANCE; FUSION; ENTRY; CELLS
Research-Areas	General \& Internal Medicine; Research \& Experimental Medicine
Web-of-Science-Categories	Medicine, General \& Internal; Medicine, Research \& Experimental
Number-of-Cited-References	27
Usage-Count-Since-2013	2
Doc-Delivery-Number	MK742