Some patterns of metallic nanoparticles' combined subchronic toxicity as exemplified by a combination of nickel and manganese oxide nanoparticles / Katsnelson Boris A.,Minigaliyeva Ilzira A.,Panov Vladimir G.,Privalova Larisa I.,Varaksin Anatoly N.,Gurvich Vladimir B.,Sutunkova Marina P.,Shur Vladimir Ya.,Shishkina Ekaterina V.,Valamina Irene E.,Makeyev Oleg H. // FOOD AND CHEMICAL TOXICOLOGY. - 2015. - V. 86, l. . - P. 351-364.

ISSN/EISSN:

0278-6915 / 1873-6351

Type:

Article

Abstract:

Stable suspensions of NiO and/or Mn3O4 nanoparticles with a mean diameter of 16.7 +/- 8.2 nm and 18.4 +/- 5.4 nm, respectively, prepared by laser ablation of 99.99\% pure metals in de-ionized water were repeatedly injected IP to rats at a dose of 0.50 mg or 0.25 mg 3 times a week up to 18 injections, either separately or in different combinations. Many functional indices as well as histological features of the liver, spleen, kidneys and brain were evaluated for signs of toxicity. The accumulation of Ni and Mn in these organs was measured with the help of AES and EPR methods. Both metallic nanoparticles proved adversely bio-active, but those of Mn3O4 were found to be more noxious in most of the non-specific toxicity manifestations. Moreover, they induced a more marked damaging effect in the neurons of the caudate nucleus and hippocampus which' may be considered an experimental correlate of manganese-induced parkinsonism. Mathematical analysis based on the Response Surface Methodology (RSM) revealed a diversity of combined toxicity types depending not only on particular effects these types are assessed for but on their level as well. The prognostic power of the RSM model proved satisfactory. (C) 2015 Elsevier Ltd. All rights reserved.

Author keywords:

Nanoparticles; Manganese (II,III) oxide; Nickel (II) oxide; Subchronic toxicity; Mathematical analysis of combined action INTRATRACHEAL INSTILLATION; URIC-ACID; BIOPROTECTORS; ATTENUATION; EXPOSURE; CELLS; LUNG; INTOXICATION; PHAGOCYTOSIS; GENOTOXICITY

DOI:

10.1016/j.fct.2015.11.012

Web of Science ID:

ISI:000368203200038

Соавторы в МНС:

Другие поля

Поле	Значение
Month	DEC
Publisher	PERGAMON-ELSEVIER SCIENCE LTD
Address	THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
Language	English
EISSN	1873-6351
Keywords-Plus	INTRATRACHEAL INSTILLATION; URIC-ACID; BIOPROTECTORS; ATTENUATION; EXPOSURE; CELLS; LUNG; INTOXICATION; PHAGOCYTOSIS; GENOTOXICITY
Research-Areas	Food Science \& Technology; Toxicology
Web-of-Science-Categories	Food Science \& Technology; Toxicology
Author-Email	bkaznelson@etel.ru
ResearcherID-Numbers	Makeyev, Oleg/G-5511-2017 Shishkina, Ekaterina/I-1829-2017 Shur, Vladimir/J-9078-2015
ORCID-Numbers	Shishkina, Ekaterina/0000-0002-2574-7472
Number-of-Cited-References	38
Usage-Count-Last-180-days	9
Usage-Count-Since-2013	23
Journal-ISO	Food Chem. Toxicol.
Doc-Delivery-Number	DB0MW