Chemoenzymatic arabinosylation of 2-aminopurines bearing the chiral fragment of 7,8-difluoro-3-methyl-3,4-dihydro-2H-{[}1,4]benzoxazines / Eletskaya Barbara Z.,Konstantinova Irina D.,Paramonov Alexander S.,Esipov Roman S.,Gruzdev Dmitry A.,Vigorov Alexey Yu.,Levit Galina L.,Miroshnikov Anatoly I.,Krasnov Victor P.,Charushin Valery N. // MENDELEEV COMMUNICATIONS. - 2016. - V. 26, l. 1. - P. 6-8.

ISSN/EISSN:

0959-9436 / 1364-551X

Type:

Article

Abstract:

Chemoenzymatic transglycosylation of 2-aminopurine conjugates with enantiomerically pure 7,8-difiuoro-3-methyl-3,4-dihydro-2H-{[}1,4]benzoxazines under the action of recombinant E. coli purine nucleoside phosphorylase afforded the corresponding arabinofuranosides, yields of the target compounds being dependent on both the structure and configuration of the fragment of heterocyclic amine attached at C-6 position of purine moiety.

Author keywords:

ADENOSINE RECEPTOR AGONISTS; TRIFLUOROACETIC-ACID; PURINE DERIVATIVES; CELL-DEATH; INHIBITORS; NUCLEOSIDES; CLOFARABINE; LIGANDS; ANALOGS; KINASE

DOI:

10.1016/j.mencom.2016.01.003

Web of Science ID:

ISI:000370901100003

Соавторы в МНС:

Другие поля

Поле	Значение
Month	JAN-FEB
Publisher	ELSEVIER SCIENCE BV
Address	PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
Language	English
EISSN	1364-551X
Keywords-Plus	ADENOSINE RECEPTOR AGONISTS; TRIFLUOROACETIC-ACID; PURINE DERIVATIVES; CELL-DEATH; INHIBITORS; NUCLEOSIDES; CLOFARABINE; LIGANDS; ANALOGS; KINASE
Research-Areas	Chemistry
Web-of-Science-Categories	Chemistry, Multidisciplinary
Author-Email	ca@ios.uran.ru
ResearcherID-Numbers	Miroshnikov, Anatoly/G-5017-2017
Funding-Acknowledgement	Russian Science Foundation {[}14-13-01077]
Funding-Text	This work was supported by the Russian Science Foundation (grant no. 14-13-01077).
Number-of-Cited-References	25
Usage-Count-Since-2013	2
Journal-ISO	Mendeleev Commun.
Doc-Delivery-Number	DE8QJ