Synthesis of novel purin-6-yl conjugates with heterocyclic amines linked via 6-aminohexanoyl fragment / Krasnov Victor P.,Gruzdev Dmitry A.,Chulakov Evgeny N.,Vigorov Alexey Yu.,Musiyak Vera V.,Matveeva Tatyana V.,Tumashov Andrey A.,Levit Galina L.,Charushin Valery N. // MENDELEEV COMMUNICATIONS. - 2015. - V. 25, l. 6. - P. 412-414.

ISSN/EISSN:

0959-9436 / 1364-551X

Type:

Article

Abstract:

Novel conjugates of purine and 2-aminopurine linked with heterocyclic amines, including chiral derivatives of 3,4-dihydro-2H-{[}1,4]benzoxazine, 3,4-dihydro-2H-{[}1,4]benzothiazine and 1,2,3,4-tetrahydroquinoline, by 6-aminohexanoyl fragment at the 6-position of purine moiety were obtained. For this purpose, replacement of the chlorine atom in 2-amino-6-chloropurine or 6-chloropurine by direct nucleophilic substitution reaction with 6-aminohexanamides or the coupling of 6-(purin-6-ylamino)-6-hexanoic acid with nitrogen heterocycles were used.

Author keywords:

REGULATORY PARTICLE; PURINE DERIVATIVES; PEPTOID INHIBITOR; ADENOSINE; KINASE; IDENTIFICATION; DISCOVERY; ANALOGS; POTENT; RNA

DOI:

10.1016/j.mencom.2015.11.003

Web of Science ID:

ISI:000367761800003

Соавторы в МНС:

Другие поля

Поле	Значение
Month	NOV-DEC
Publisher	ELSEVIER SCIENCE BV
Address	PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
Language	English
EISSN	1364-551X
Keywords-Plus	REGULATORY PARTICLE; PURINE DERIVATIVES; PEPTOID INHIBITOR; ADENOSINE; KINASE; IDENTIFICATION; DISCOVERY; ANALOGS; POTENT; RNA
Research-Areas	Chemistry
Web-of-Science-Categories	Chemistry, Multidisciplinary
Author-Email	ca@ios.uran.ru
Funding-Acknowledgement	Russian Science Foundation {[}14-13-01077]
Funding-Text	We are grateful to Dr. Ilya N. Ganebnykh for recording HRMS spectra and Dr. Mikhail I. Kodess for recording NMR spectra. This work was supported by the Russian Science Foundation (grant no. 14-13-01077).
Number-of-Cited-References	30
Usage-Count-Last-180-days	1
Usage-Count-Since-2013	4
Journal-ISO	Mendeleev Commun.
Doc-Delivery-Number	DA4HU