Sex Differences in Behavioral Reactions and the Character of Audiogenic Seizures in Krushinsky-Molodkina Rat Strain / Krivopalov S. A.,Yushkov B. G. // ZHURNAL VYSSHEI NERVNOI DEYATELNOSTI IMENI I P PAVLOVA. - 2015. - V. 65, l. 6. - P. 756-765.

ISSN/EISSN:

0044-4677 / нет данных

Type:

Article

Abstract:

In the ``open field{''} test it was found that locomotor activity in Krushinsky-Molodkina rat strain (KM) is higher than in nonlinear animals At the same time, both groups of animals had the same sex differences: a locomotor activity of females was higher than males. Sex differences in exploratory activities are not inherent for KM rats, while the female outbred animals are significantly higher than males in their level of such activities. The greatest differences in behavior between KM rats and outbred animals were found in anxiety level, which is much higher in the first case. Furthermore just KM rats are characterized by clear sex differences the males demonstrate more anxious and fearful respond to unfamiliar surroundings than females. Male and female KM rats differ not only in behavior but also in the character of epileptiform seizures induced by loud sound: wild running, tonic-clonic and clonic convulsions occur faster in females and the resumption of breathing-in males. The interconnection between parameters of seizure and behavior was found for KM rats. This phenomenon is most clearly manifested in males and combine large group of indicators.

Author keywords:

epilepsy; KM rats; sex differences; open field; audiogenic epileptiform seizure SUSCEPTIBILITY; EPILEPSY; PENTYLENETETRAZOL; CONVULSIONS; PICROTOXIN; PATHOLOGY; MORPHINE; MICE

DOI:

10.7868/S0044467715050068

Web of Science ID:

ISI:000370212600011

Соавторы в МНС:

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Другие поля

Поле	Значение
Month	NOV-DEC
Publisher	MEZHDUNARODNAYA KNIGA
Address	39 DIMITROVA UL., MOSCOW, 113095, RUSSIA
Language	Russian
Keywords-Plus	SUSCEPTIBILITY; EPILEPSY; PENTYLENETETRAZOL; CONVULSIONS; PICROTOXIN; PATHOLOGY; MORPHINE; MICE
Research-Areas	Neurosciences \& Neurology; Physiology
Web-of-Science-Categories	Neurosciences; Physiology
Author-Email	s.krivopalov@gmail.com
Number-of-Cited-References	26
Journal-ISO	Zhurnal Vyss. Nervn. Deyatelnosti Im. I P Pavlov.
Doc-Delivery-Number	DD8YK