Enantioselective microbial synthesis of (S)-7,8-difluoro-3,4-dihydro-3-methyl-2H-{[}1,4]benzoxazine / Chulakov E. N.,Levit G. L.,Tumashov A. A.,Lugovskaya N. P.,Remezovskaya N. B.,Maksimov A. Yu.,Demakov V. A.,Krasnov V. P. // RUSSIAN CHEMICAL BULLETIN. - 2015. - V. 64, l. 5. - P. 1097-1099.

ISSN/EISSN:

1066-5285 / 1573-9171

Type:

Article

Abstract:

New strains of Rhodococcus erythropolis 25 and Microbacterium paraoxydans 20-11c actinobacteria were used to obtain (S)-7,8-difluoro-3,4-dihydro-3-methyl-2H-{[}1,4]benzoxazine (99.6\% ee) by enantioselective microbial hydrolysis of the corresponding racemic N-acetyl derivative.

Author keywords:

kinetic resolution; biotransformation; hydrolysis; enantioselectivity; amide ACYLATIVE KINETIC RESOLUTION; N-PHTHALOYL-(S)-AMINO ACYL CHLORIDES; HETEROCYCLIC AMINES; (+/-)-2,3-DIHYDRO-3-METHYL-4H-1,4-BENZOXAZINE; (+/-)-2-METHYL-1,2,3,4-TETRAHYDROQUINOLINE; (+/-)-2-METHYLINDOLINE; (S)-NAPROXEN; AGENT

DOI:

10.1007/s11172-015-0985-4

Web of Science ID:

ISI:000369426300018

Соавторы в МНС:

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Другие поля

Поле	Значение
Month	MAY
Publisher	SPRINGER
Address	233 SPRING ST, NEW YORK, NY 10013 USA
Language	English
EISSN	1573-9171
Keywords-Plus	ACYLATIVE KINETIC RESOLUTION; N-PHTHALOYL-(S)-AMINO ACYL CHLORIDES; HETEROCYCLIC AMINES; (+/-)-2,3-DIHYDRO-3-METHYL-4H-1,4-BENZOXAZINE; (+/-)-2-METHYL-1,2,3,4-TETRAHYDROQUINOLINE; (+/-)-2-METHYLINDOLINE; (S)-NAPROXEN; AGENT
Research-Areas	Chemistry
Web-of-Science-Categories	Chemistry, Multidisciplinary
Author-Email	ca@ios.uran.ru
Funding-Acknowledgement	Russian Foundation for Basic Research {[}13-03-96035r\_ural-a]; Ural Branch of the Russian Academy of Sciences
Funding-Text	This work was financially supported by the Russian Foundation for Basic Research (Grant No. 13-03-96035r\_ural-a) and the Comprehensive Program of the Ural Branch of the Russian Academy of Sciences.
Number-of-Cited-References	23
Usage-Count-Since-2013	3
Journal-ISO	Russ. Chem. Bull.
Doc-Delivery-Number	DC7UP