Synthesis of 4-arylamino-3-(trifluoromethyl)-pyridazines and pyridazino{[}3,4-b]quinoxalines (as by-products) from 3-aroylmethyl-2-(trifluoromethyl)quinoxalines and hydrazine hydrate / Sosnovskikh Vyacheslav Y.,Safrygin Alexander V.,Irgashev Roman A.,Ezhikova Marina A.,Kodess Mikhail I. // RSC ADVANCES. - 2016. - V. 6, l. 36. - P. 30056-30069.

ISSN/EISSN:

2046-2069 / нет данных

Type:

Article

Abstract:

A number of 4-arylamino-3-(trifluoromethyl)pyridazines were obtained in good yields via the novel reaction of 3-aroylmethyl-2-(trifluoromethyl)quinoxalines with an excess of hydrazine hydrate in refluxing n-butanol with or without acetic acid. This reaction is accompanied by the formation of side-products with the pyridazino{[}3,4-b] quinoxaline skeleton. The possible reaction mechanism was discussed.

Author keywords:

CONVENIENT SYNTHESIS; POLYAZA HETEROCYCLES; SUBSTITUTED PYRIDAZINES; NUCLEOPHILIC-REAGENTS; HYDROGEN HALIDES; QUINOXALINO<2,3-C>CINNOLINES; REARRANGEMENT; HALOGENATION; QUINOXALINE; REACTIVITY

DOI:

10.1039/c5ra27032d

Web of Science ID:

ISI:000373061600022

Соавторы в МНС:

Другие поля

Поле	Значение
Publisher	ROYAL SOC CHEMISTRY
Address	THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND
Language	English
Keywords-Plus	CONVENIENT SYNTHESIS; POLYAZA HETEROCYCLES; SUBSTITUTED PYRIDAZINES; NUCLEOPHILIC-REAGENTS; HYDROGEN HALIDES; QUINOXALINO<2,3-C>CINNOLINES; REARRANGEMENT; HALOGENATION; QUINOXALINE; REACTIVITY
Research-Areas	Chemistry
Web-of-Science-Categories	Chemistry, Multidisciplinary
Author-Email	vy.sosnovskikh@urfu.ru
ResearcherID-Numbers	Irgashev, Roman/E-5077-2017
ORCID-Numbers	Irgashev, Roman/0000-0002-8428-1748
Funding-Acknowledgement	Act 211 Government of the Russian Federation {[}02.A03.21.0006]; Ministry of Education and Science of Russian Federation
Funding-Text	This work was financially supported by the Act 211 Government of the Russian Federation, agreement No 02.A03.21.0006, and performed within the State Task from the Ministry of Education and Science of Russian Federation.
Number-of-Cited-References	47
Usage-Count-Last-180-days	1
Usage-Count-Since-2013	3
Journal-ISO	RSC Adv.
Doc-Delivery-Number	DH8QU