Some characteristics of free cell population in the airways of rats after intratracheal instillation of copper-containing nano-scale particles / Privalova L.I., Katsnelson B.A., Loginova N.V., Gurvich V.B., Shur V.Y., Beikin Y.B., Sutunkova M.P., Minigalieva I.A., Shishkina E.V., Pichugova S.V., Tulakina L.G., Beljayeva S.V. // International journal of molecular sciences. - 2014. - V. 15, l. 11. - P. 21538-21553.

ISSN:

14220067

Type:

Article

Abstract:

We used stable water suspensions of copper oxide particles with mean diameter 20 nm and of particles containing copper oxide and element copper with mean diameter 340 nm to assess the pulmonary phagocytosis response of rats to a single intratracheal instillation of these suspensions using optical, transmission electron, and semi-contact atomic force microscopy and biochemical indices measured in the bronchoalveolar lavage fluid. Although both nano and submicron ultrafine particles were adversely bioactive, the former were found to be more toxic for lungs as compared with the latter while evoking more pronounced defense recruitment of alveolar macrophages and especially of neutrophil leukocytes and more active phagocytosis. Based on our results and literature data, we consider both copper solubilization and direct contact with cellular organelles (mainly, mitochondria) of persistent particles internalized by phagocytes as probable mechanisms of their cytotoxicity.

Author keywords:

Index keywords:

copper; cuprous oxide; nanoparticle; suspension; administration and dosage; animal; bronchoalveolar lavage fluid; drug effects; endotracheal intubation; female; lung; lung alveolus macrophage; neutrop

DOI:

10.3390/ijms151121538

Смотреть в Scopus:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-84928145184&doi=10.3390%2fijms151121538&partnerID=40&md5=4bd4619130a5c877a481c2ad9279ac36

Соавторы в МНС:

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Другие поля

Поле	Значение
Link	https://www.scopus.com/inward/record.uri?eid=2-s2.0-84928145184&doi=10.3390%2fijms151121538&partnerID=40&md5=4bd4619130a5c877a481c2ad9279ac36
Affiliations	The Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, 30 Popov Str., Ekaterinburg 620014, Russia. privalovali@yahoo.com; The Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, 30 Popov Str., Ekaterinburg 620014, Russia. bkaznelson@etel.ru; The Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, 30 Popov Str., Ekaterinburg 620014, Russia. loginova.Nadzhda@mail.ru; The Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, 30 Popov Str., Ekaterinburg 620014, Russia. gurvich@ymrc.ru; The Institute of Natural Sciences, the Ural Federal University, Ekaterinburg 620000, Russia. vladimir.shur@usu.ru; The City Clinical Diagnostics Centre, 28 Dekabristov Str., Ekaterinburg 620142, Russia. beikin@mail.ru; The Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, 30 Popov Str., Ekaterinburg 620014, Russia. sutunkova@ymrc.ru; The Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, 30 Popov Str., Ekaterinburg 620014, Russia. ilzira-minigalieva@yandex.ru; The Institute of Natural Sciences, the Ural Federal University, Ekaterinburg 620000, Russia. ekaterina.shishkina@labfer.usu.ru; The City Clinical Diagnostics Centre, 28 Dekabristov Str., Ekaterinburg 620142, Russia. ekb-lem@mail.ru; The City Clinical Diagnostics Centre, 28 Dekabristov Str., Ekaterinburg 620142, Russia. sdiklein@gmail.com; The City Clinical Diagnostics Centre, 28 Dekabristov Str., Ekaterinburg 620142, Russia. kdc_boss@mail.ru
Chemicals/CAS	copper, 15158-11-9, 7440-50-8; cuprous oxide, 1317-39-1; Copper; cuprous oxide; Suspensions
PubMed ID	25421246
Language of Original Document	English
Abbreviated Source Title	Int J Mol Sci
Source	Scopus