A rapid and facile synthesis of new spiropyrimidines from 5-(2-arylethylidene-2-oxo)-1,3-dimethylpyrimidine-2,4,6-triones / Gozalishvili L.L., Beryozkina T.V., Omelchenko I.V., Zubatyuk R.I., Shishkin O.V., Kolos N.N. // Tetrahedron. - 2008. - V. 64, l. 37. - P. 8759-8765.

ISSN:

00404020

Type:

Article

Abstract:

A series of new tetraazaspiro[5,5]-undec-4-ene-2,7,9,11-tetraones have been obtained by reaction of 5-(2-arylethylidene-2-oxo)-1,3-dimethylpyrimidine-2,4,6-triones with ureas. A three-component one-pot procedure to the spiranes synthesis was also developed. One-pot reaction of arylglyoxals, 1,3-dimethylbarbituric acid, and dimethylurea led to imidazolyl-1,3-dimethylbarbituric acids. Mechanisms of studied reactions were discussed. © 2008 Elsevier Ltd. All rights reserved.

Author keywords:

α,β-Unsaturated ketones; Arylglyoxals; Knoevenagel reaction; One-pot synthesis; Spiropyrimidines; Ureas

Index keywords:

barbituric acid derivative; dimethylurea; glyoxal derivative; pyrimidine derivative; urea; article; carbon nuclear magnetic resonance; chemical reaction; one pot synthesis; priority journal; proton nu

DOI:

10.1016/j.tet.2008.06.097

Смотреть в Scopus:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-48049114187&doi=10.1016%2fj.tet.2008.06.097&partnerID=40&md5=6bc1d60c3ef4d98dc423c74e35d9e2e7

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Другие поля

Поле	Значение
Link	https://www.scopus.com/inward/record.uri?eid=2-s2.0-48049114187&doi=10.1016%2fj.tet.2008.06.097&partnerID=40&md5=6bc1d60c3ef4d98dc423c74e35d9e2e7
Affiliations	Organic Chemistry Department, V.N. Karazin Kharkiv National University, Svoboda sq. 4, 61077 Kharkiv, Ukraine; STC 'Institute of Single Crystals', Lenina ave. 60, 61001 Kharkiv, Ukraine
Author Keywords	α,β-Unsaturated ketones; Arylglyoxals; Knoevenagel reaction; One-pot synthesis; Spiropyrimidines; Ureas
Chemicals/CAS	dimethylurea, 1320-50-9; urea, 57-13-6
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Correspondence Address	Kolos, N.N.; Organic Chemistry Department, V.N. Karazin Kharkiv National University, Svoboda sq. 4, 61077 Kharkiv, Ukraine; email: kolos@univer.kharkov.ua
CODEN	TETRA
Language of Original Document	English
Abbreviated Source Title	Tetrahedron
Source	Scopus