Scientific foundations for the creation of antiviral and antibacterial preparations / Chupakhin O. N.,Charushin V. N.,Rusinov V. L. // HERALD OF THE RUSSIAN ACADEMY OF SCIENCES. - 2016. - V. 86, l. 3. - P. 206-212.

ISSN/EISSN:

1019-3316 / 1555-6492

Type:

Article

Abstract:

The results of the Ural scientific school's organic chemists on the creation of antiviral and antibacterial, including antitubercular, chemopreparations are considered. Basic research data were generalized on the synthesis and study of antiviral activity and the establishment of the metabolism and mechanism of azoloazine series compounds-azaanalogs of adenine and guanine, as well as their nucleosides, which led to the creation of a new family of antiviral substances. One of them, triazavirin, has become a regular therapeutic fixture as an antiflu preparation. The results of synthetic and biological studies on substituted pyrimidines, nucleosides of the benzimidazole and purine series, and other biologically active azaheterocycles are also discussed.

Author keywords:

triazavirin; triazide and other azoloazine derivatives; protein disulfide isomerase inhibitors; nucleosides of fluorine-containing benzimidazoles and purines; antibacterial fluoroquinolones; bacterial CHEMOENZYMATIC SYNTHESIS; TRIAZAVIRIN; 2'-DEOXYRIBONUCLEOSIDES; ANTIMYCOBACTERIAL; ENCEPHALITIS; EFFICACY; VIRUS

DOI:

10.1134/S1019331616030163

Web of Science ID:

ISI:000379583400012

Соавторы в МНС:

Другие поля

Поле	Значение
Month	MAY
Publisher	MAIK NAUKA/INTERPERIODICA/SPRINGER
Address	233 SPRING ST, NEW YORK, NY 10013-1578 USA
Language	English
EISSN	1555-6492
Keywords-Plus	CHEMOENZYMATIC SYNTHESIS; TRIAZAVIRIN; 2'-DEOXYRIBONUCLEOSIDES; ANTIMYCOBACTERIAL; ENCEPHALITIS; EFFICACY; VIRUS
Research-Areas	History \& Philosophy of Science; Science \& Technology - Other Topics
Web-of-Science-Categories	History \& Philosophy Of Science; Multidisciplinary Sciences
Author-Email	chupakhin@ios.uran.ru charushin@ios.uran.ru v.rusinov@ios.uran.ru
Number-of-Cited-References	22
Usage-Count-Last-180-days	2
Usage-Count-Since-2013	3
Journal-ISO	Her. Russ. Acad. Sci.
Doc-Delivery-Number	DR0FM