pHLIP-modified magnetic nanoparticles for targeting acidic diseased tissue / Demin A. M.,Pershina A. G.,Nevskaya K. V.,Efimova L. V.,Shchegoleva N. N.,Uimin M. A.,Kuznetsov D. K.,Shur V. Ya.,Krasnov V. P.,Ogorodova L. M. // RSC ADVANCES. - 2016. - V. 6, l. 65. - P. 60196-60199.

ISSN/EISSN:
2046-2069 / нет данных
Type:
Article
Abstract:
Covalent immobilization of a pH-low insertion peptide (pHLIP) onto Fe3O4 magnetic nanoparticles was carried out resulting in the formation of MRI-visible materials able to specifically accumulate in acidic damaged tissue. The pH-dependent pHLIP-mediated binding of the obtained nanoconjugates to cells in acidic environment was demonstrated on HTC cells in vitro and in a mouse LLC tumour model in vivo.
Author keywords:
PEPTIDE; SURFACE; PROLIFERATION; TRANSLOCATION; NANOMEDICINE; TUMORS; ASSAY; IRON
DOI:
10.1039/c6ra13178f
Web of Science ID:
ISI:000379351600038
Соавторы в МНС:
Другие поля
Поле Значение
Publisher ROYAL SOC CHEMISTRY
Address THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND
Language English
Keywords-Plus PEPTIDE; SURFACE; PROLIFERATION; TRANSLOCATION; NANOMEDICINE; TUMORS; ASSAY; IRON
Research-Areas Chemistry
Web-of-Science-Categories Chemistry, Multidisciplinary
Author-Email allysyz@mail.ru
ResearcherID-Numbers Demin, Alexander/L-7353-2016 Pershina, Alexandra/C-3053-2015 Kuznetsov, Dmitry/K-8081-2015 Щеголева, Нина/B-6589-2017 Efimova, Lina/L-7345-2016 Ogorodova, Ludmila/S-5058-2016
ORCID-Numbers Efimova, Lina/0000-0002-7168-1419 Ogorodova, Ludmila/0000-0002-2962-1076 Shur, Vladimir/0000-0002-6970-7798 Demin, Alexander/0000-0002-4132-2327
Funding-Acknowledgement Russian Science Foundation {[}14-15-00247]
Funding-Text This work was supported by the Russian Science Foundation (project no. 14-15-00247). The authors thank Prof. Sergey V. Vtorushin for conduct the histological analysis, Dr Igor A. Klimov for helping with animal experiments, Artyom A. Minin for providing DLS analysis and Oleg B. Shevelev for assisting in MRI scanning.
Number-of-Cited-References 21
Usage-Count-Last-180-days 1
Usage-Count-Since-2013 4
Journal-ISO RSC Adv.
Doc-Delivery-Number DQ6YA