Mechano-electric feedback in one-dimensional model of myocardium / Vikulova Nathalie A.,Katsnelson Leonid B.,Kursanov Alexander G.,Solovyova Olga,Markhasin Vladimir S. // JOURNAL OF MATHEMATICAL BIOLOGY. - 2016. - V. 73, l. 2. - P. 335-366.

ISSN/EISSN:

0303-6812 / 1432-1416

Type:

Article

Abstract:

We utilized our earlier developed 1D mathematical model of the heart muscle strand to study contribution of the bilateral interactions between excitation and contraction on the cellular and tissue levels to the local and global myocardium function. Numerical experiments on the model showed that an initially uniform strand, formed on the inherently identical cells, became functionally heterogeneous due to the asynchronous excitation via the electrical wave spread. Mechanical interactions between the cells and the mechano-electric feedback beat-to-beat affect the functional characteristics of coupled cardiomyocytes further, adjusting their electrical and mechanical heterogeneity to the activation timing. Model simulations showed that functional heterogeneity increases with an enlarged spatial extension of the myocardial strand (in terms of the longer slack length not a higher stretch of the strand), demonstrating a special role of the heart size in its function. Model analysis suggests that cooperative mechanisms of myofilament calcium activation contribute essentially to the generation of cellular functional heterogeneity in contracting cardiac tissue.

Author keywords:

Cardiac excitation-contraction coupling; Mechano-electric feedback; Heterogeneous myocardium; Mathematical modeling HETEROGENEOUS MYOCARDIUM; MECHANICAL-ACTIVITY; CARDIAC-MUSCLE; ARRHYTHMIAS; TISSUE; CARDIOMYOCYTES; DISTURBANCES

DOI:

10.1007/s00285-015-0953-5

Web of Science ID:

ISI:000379498700004

Соавторы в МНС:

Другие поля

Поле	Значение
Month	AUG
Publisher	SPRINGER HEIDELBERG
Address	TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
Language	English
EISSN	1432-1416
Keywords-Plus	HETEROGENEOUS MYOCARDIUM; MECHANICAL-ACTIVITY; CARDIAC-MUSCLE; ARRHYTHMIAS; TISSUE; CARDIOMYOCYTES; DISTURBANCES
Research-Areas	Life Sciences \& Biomedicine - Other Topics; Mathematical \& Computational Biology
Web-of-Science-Categories	Biology; Mathematical \& Computational Biology
Author-Email	n.vikulova@iip.uran.ru
ResearcherID-Numbers	Solovyova, Olga/T-8232-2017 Balakina-Vikulova, Nathalie/D-9833-2015
ORCID-Numbers	Balakina-Vikulova, Nathalie/0000-0003-1316-4437
Funding-Acknowledgement	Russian Science Foundation {[}14-35-00005]
Funding-Text	This work was supported by The Russian Science Foundation (\#14-35-00005).
Number-of-Cited-References	28
Usage-Count-Last-180-days	1
Usage-Count-Since-2013	7
Journal-ISO	J. Math. Biol.
Doc-Delivery-Number	DQ8YX