Effects of Enhanced Sodium Currents in Mathematical Model of Heterogeneous Myocardium / Vikulova Nathalie,Khokhlova Anastasia,Katsnelson Leonid B.,Solovyova Olga // . - 2015. - V. 42, l. . - P. 445-448.

ISSN/EISSN:

0276-6574 / нет данных

Type:

Proceedings Paper

Abstract:

Cardiac arrhythmias and long QT syndrome may be associated with increased sodium currents. Possible effects of enhanced function of sodium channels on the transmural gradient in the electrical and mechanical properties of myocardium have not been sufficiently studied. We used our cellular mathematical models to investigate effects of an increased late sodium current on the electromechanical coupling in single subendocardial and subepicardial cells and in a strand of transmurally heterogeneous myocardium. Modeling results predicted that subepicardial cells are more vulnerable to rhythm disturbances than single subendocardial cells under these pathological conditions. Within the transmurally heterogeneous strand, mechanical and electrical interactions between such abnormal cells affected the patterns of electromechanical disturbances as compared to the single cells. This allowed myocardium to contract even in those conditions where single EPI cells lost contractility.

Author keywords:

VENTRICLE

DOI:

нет данных

Web of Science ID:

ISI:000380374700113

Соавторы в МНС:

Другие поля

Поле	Значение
Editor	Murray, A
Booktitle	2015 COMPUTING IN CARDIOLOGY CONFERENCE (CINC)
Series	Computing in Cardiology Series
Note	2015 Comp in Cardiol Conference (CinC), Comp in Cardiol 2015, nice, FRANCE, SEP 06-09, 2015
Publisher	IEEE
Address	345 E 47TH ST, NEW YORK, NY 10017 USA
Language	English
ISBN	978-1-5090-0685-4
Keywords-Plus	VENTRICLE
Research-Areas	Computer Science; Engineering
Web-of-Science-Categories	Computer Science, Interdisciplinary Applications; Engineering, Multidisciplinary; Engineering, Biomedical
Author-Email	n.vikulova@iip.uran.ru
ResearcherID-Numbers	Solovyova, Olga/T-8232-2017 Balakina-Vikulova, Nathalie/D-9833-2015
ORCID-Numbers	Balakina-Vikulova, Nathalie/0000-0003-1316-4437
Number-of-Cited-References	11
Doc-Delivery-Number	BF1CZ