Role of Mechanics in Rhythm Disturbances in 1D Mathematical Model of Myocardial Tissue with Local Ca2+-Overload / Kursanov Alexander,Solovyova Olga,Katsnelson Leonid,Markhasin Vladimir S. // . - 2015. - V. 42, l. . - P. 549-552.

ISSN/EISSN:

0276-6574 / нет данных

Type:

Proceedings Paper

Abstract:

Possible contribution of the mechanics to the arrhythmogenesis in Ca2+ overloaded cardiomyocytes has been under appreciated. Earlier developed mathematical model of cardiomyocyte electromechanical function predicted a significant role of intra-and extracellular mechanical factors in triggering rhythm abnormalities. We utilized the cellular model to study effects of the electromechanical coupling between cardiomyocytes in a 1D heterogeneous muscle strand comprised normal (N) and sub-critical (SC) cardiomyocytes with moderately decreased Na+-K+ pump activity. The single SC cardiomyocytes did not demonstrate spontaneous activity during isometric contractions at a reference length. In the tissue, excitation spreads via electro-diffusional cell coupling and activates cell contractions and force development. Mechanical interactions between N- and SC-cells in the tissue resulted in the spontaneous activity emerged in the SC zone between the regular stimuli. The results suggest that ectopic activity may emerge in a rather small SC-region and expand by capturing normal regions in myocardium due to the electromechanical coupling between cardiomyocytes.

Author keywords:

нет данных

DOI:

нет данных

Web of Science ID:

ISI:000380374700139

Соавторы в МНС:

Другие поля

Поле	Значение
Editor	Murray, A
Booktitle	2015 COMPUTING IN CARDIOLOGY CONFERENCE (CINC)
Series	Computing in Cardiology Series
Note	2015 Comp in Cardiol Conference (CinC), Comp in Cardiol 2015, nice, FRANCE, SEP 06-09, 2015
Publisher	IEEE
Address	345 E 47TH ST, NEW YORK, NY 10017 USA
Language	English
ISBN	978-1-5090-0685-4
Research-Areas	Computer Science; Engineering
Web-of-Science-Categories	Computer Science, Interdisciplinary Applications; Engineering, Multidisciplinary; Engineering, Biomedical
Author-Email	alexander.kursanov@gmail.com
ResearcherID-Numbers	Solovyova, Olga/T-8232-2017
Number-of-Cited-References	4
Doc-Delivery-Number	BF1CZ