Microfluidic separation of magnetic nanoparticles on an ordered array of magnetized micropillars / Orlandi G.,Kuzhir P.,Izmaylov Y.,Marins J. Alves,Ezzaier H.,Robert L.,Doutre F.,Noblin X.,Lomenech C.,Bossis G.,Meunier A.,Sandoz G.,Zubarev A. // PHYSICAL REVIEW E. - 2016. - V. 93, l. 6.

ISSN/EISSN:

2470-0045 / 2470-0053

Type:

Article

Abstract:

Microfluidic separation of magnetic particles is based on their capture by magnetized microcollectors while the suspending fluid flows past the microcollectors inside a microchannel. Separation of nanoparticles is often challenging because of strong Brownian motion. Low capture efficiency of nanoparticles limits their applications in bioanalysis. However, at some conditions, magnetic nanoparticles may undergo field-induced aggregation that amplifies the magnetic attractive force proportionally to the aggregate volume and considerably increases nanoparticle capture efficiency. In this paper, we have demonstrated the role of such aggregation on an efficient capture of magnetic nanoparticles (about 80 nm in diameter) in a microfluidic channel equipped with a nickel micropillar array. This array was magnetized by an external uniform magnetic field, of intensity as low as 6-10 kA/m, and experiments were carried out at flow rates ranging between 0.3 and 30 mu L/min. Nanoparticle capture is shown to be mostly governed by the Mason number Ma, while the dipolar coupling parameter alpha does not exhibit a clear effect in the studied range, 1.4< alpha < 4.5. The capture efficiency Lambda shows a strongly decreasing Mason number behavior, Lambda alpha Ma(-1.78) within the range 32 <= Ma <= 3250. We have proposed a simple theoretical model which considers destructible nanoparticle chains and gives the scaling behavior, Lambda alpha Ma-(1.7), close to the experimental findings.

Author keywords:

CANCER-CELLS; PATTERNS; CAPTURE; DEVICE

DOI:

10.1103/PhysRevE.93.062604

Web of Science ID:

ISI:000377508500009

Соавторы в МНС:

—

Другие поля

Поле	Значение
Month	JUN 10
Publisher	AMER PHYSICAL SOC
Address	ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA
Language	English
Article-Number	062604
EISSN	2470-0053
Keywords-Plus	CANCER-CELLS; PATTERNS; CAPTURE; DEVICE
Research-Areas	Physics
Web-of-Science-Categories	Physics, Fluids \& Plasmas; Physics, Mathematical
Author-Email	kuzhir@unice.fr
ORCID-Numbers	Kuzhir, Pavel/0000-0001-7089-6197 Sandoz, Guillaume/0000-0003-1251-0852
Funding-Acknowledgement	CNRS/Ural Federal University {[}PICS 6102]; French RENATECH network; CNPq {[}203100/2014-0]; FSB; Program of Ministry of Science and Education of the Russian Federation {[}3.12.2014/K]; Russian Fund of Fundamental Investigations {[}14-08-00283]
Funding-Text	The authors are very grateful to the LPMC director for financial support. This work was partly supported by Project No. PICS 6102 CNRS/Ural Federal University as well as by the French RENATECH network and its FEMTO-ST technological facility which has fabricated the micropillar arrays. One of the authors (J.A.M.) acknowledges CNPq through its postdoctoral fellowship (Ref. No. 203100/2014-0), another author (H.E.) acknowledges FSB through its Ph.D. collaboration fellowship, and the author A.Z. acknowledges the Program of Ministry of Science and Education of the Russian Federation (Ref. No. 3.12.2014/K) as well as the Russian Fund of Fundamental Investigations, Project No. 14-08-00283.
Number-of-Cited-References	28
Usage-Count-Last-180-days	1
Usage-Count-Since-2013	29
Journal-ISO	Phys. Rev. E
Doc-Delivery-Number	DO0ZT